人类与智能代理互动时，行为相似但道德感更低，需关注设计伦理。

Interactive intelligent agents are being integrated across society. Despite achieving human-like capabilities, humans' responses to these agents remain poorly understood, with research fragmented across disciplines. We conducted a first systematic synthesis comparing a range of psychological and behavioural responses in matched human-agent vs. human-human dyadic interactions. A total of 162 eligible studies (146 contributed to the meta-analysis; 468 effect sizes) were included in the systematic review and meta-analysis, which integrated frequentist and Bayesian approaches. Our results indicate that individuals exhibited less prosocial behaviour and moral engagement when interacting with agents vs. humans. They attributed less agency and responsibility to agents, perceiving them as less competent, likeable, and socially present. In contrast, individuals' social alignment (i.e., alignment or adaptation of internal states and behaviours with partners), trust in partners, personal agency, task performance, and interaction experiences were generally comparable when interacting with agents vs. humans. We observed high effect-size heterogeneity for many subjective responses (i.e., social perceptions of partners, subjective trust, and interaction experiences), suggesting context-dependency of partner effects. By examining the characteristics of studies, participants, partners, interaction scenarios, and response measures, we also identified several moderators shaping partner effects. Overall, functional behaviours and interactive experiences with agents can resemble those with humans, whereas fundamental social attributions and moral/prosocial concerns lag in human-agent interactions. Agents are thus afforded instrumental value on par with humans but lack comparable intrinsic value, providing practical implications for agent design and regulation.