arXiv:2509.24165cs.CVcs.AI2025-09

用3D背面数据生成侧位X光片,无辐射精准评估脊柱弯曲。

LatXGen: Towards Radiation-Free and Accurate Quantitative Analysis of Sagittal Spinal Alignment Via Cross-Modal Radiographic View Synthesis

  • 通过RGBD图像生成侧位脊柱X光片,实现无辐射评估。
  • 在3264对数据上验证,生成图像更真实且精度更高。
  • 适合脊柱侧弯筛查与长期随访的临床医生使用。

青少年特发性脊柱侧弯(AIS)是一种复杂的三维脊柱畸形,准确的形态评估需同时分析冠状面和矢状面结构。尽管已有研究在无辐射的冠状面评估方面取得进展,但无需电离辐射的矢状面评估仍缺乏可靠方法。为此,本文提出LatXGen,一种新型生成框架,可从裸背的后前向红绿蓝-深度(RGBD)图像合成真实的侧位脊柱X光片,实现无辐射、精准的矢状面评估。该框架解决两大挑战:(1)基于前后表面几何推断侧位脊柱形态变化;(2)完成从RGBD输入到放射影像域的跨模态转换。采用双阶段架构,逐步估计侧位脊柱结构并合成对应影像。为提升解剖一致性,引入基于注意力的快速傅里叶卷积(FFC)模块融合RGBD特征与3D关键点,并设计空间形变网络(SDN)建模侧位形态差异。此外,构建首个大规模配对数据集,包含3,264组RGBD与侧位X光片配对数据。实验表明,LatXGen生成的图像具有高解剖准确性,且在视觉保真度与定量指标上优于现有GAN方法。本研究为矢状面脊柱评估提供了有前景的无辐射解决方案,推动了AIS的全面评估发展。

原文摘要 · Abstract (English)

Adolescent Idiopathic Scoliosis (AIS) is a complex three-dimensional spinal deformity, and accurate morphological assessment requires evaluating both coronal and sagittal alignment. While previous research has made significant progress in developing radiation-free methods for coronal plane assessment, reliable and accurate evaluation of sagittal alignment without ionizing radiation remains largely underexplored. To address this gap, we propose LatXGen, a novel generative framework that synthesizes realistic lateral spinal radiographs from posterior Red-Green-Blue and Depth (RGBD) images of unclothed backs. This enables accurate, radiation-free estimation of sagittal spinal alignment. LatXGen tackles two core challenges: (1) inferring sagittal spinal morphology changes from a lateral perspective based on posteroanterior surface geometry, and (2) performing cross-modality translation from RGBD input to the radiographic domain. The framework adopts a dual-stage architecture that progressively estimates lateral spinal structure and synthesizes corresponding radiographs. To enhance anatomical consistency, we introduce an attention-based Fast Fourier Convolution (FFC) module for integrating anatomical features from RGBD images and 3D landmarks, and a Spatial Deformation Network (SDN) to model morphological variations in the lateral view. Additionally, we construct the first large-scale paired dataset for this task, comprising 3,264 RGBD and lateral radiograph pairs. Experimental results demonstrate that LatXGen produces anatomically accurate radiographs and outperforms existing GAN-based methods in both visual fidelity and quantitative metrics. This study offers a promising, radiation-free solution for sagittal spine assessment and advances comprehensive AIS evaluation.

无辐射脊柱侧弯图像生成医学影像

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