用结构信息提升抗体优化效率，但语言模型软约束让纯序列方法也能追平。

Bayesian optimization is a natural candidate for the engineering of antibody therapeutic properties, which is often iterative and expensive. However, finding the optimal choice of surrogate model for optimization over the highly structured antibody space is difficult, and may differ depending on the property being optimized. Moreover, to the best of our knowledge, no prior works have attempted to incorporate structural information into antibody Bayesian optimization. In this work, we explore different approaches to incorporating structural information into Bayesian optimization, and compare them to a variety of sequence-only approaches on two different antibody properties, binding affinity and stability. In addition, we propose the use of a protein language model-based ``soft constraint,'' which helps guide the optimization to promising regions of the space. We find that certain types of structural information improve data efficiency in early optimization rounds for stability, but have equivalent peak performance. Moreover, when incorporating the protein language model soft constraint we find that the data efficiency gap is diminished for affinity and eliminated for stability, resulting in sequence-only methods that match the performance of structure-based methods, raising questions about the necessity of structure in Bayesian optimization for antibodies.