arXiv:2509.26440cs.AI2025-09被引 1

用Transformer模型提升乳腺MRI良恶性分类准确率,达0.92 AUC。

Transformer Classification of Breast Lesions: The BreastDCEDL_AMBL Benchmark Dataset and 0.92 AUC Baseline

  • 基于SegFormer的Transformer框架,结合语义分割定位恶性像素分布。
  • 患者层面100%敏感性、67%特异性,可减少三分之一不必要的活检。
  • 首个标准化公开数据集,解决良性病灶标注缺失的瓶颈问题。

乳腺动态增强磁共振成像对癌症检测与治疗规划至关重要,但其临床应用受限于特异性差,导致假阳性率高和不必要的活检。本研究提出一种基于Transformer的自动分类框架,用于动态对比增强MRI中乳腺病灶的良恶性判别。采用SegFormer架构,在病灶级别分类中达到0.92 AUC,患者层面实现100%敏感性和67%特异性,有望在不遗漏恶性病例的前提下,减少约三分之一的非必要活检。模型通过语义分割量化恶性像素的空间分布,提供可解释的预测结果,支持临床决策。为建立可复现的基准,我们构建了BreastDCEDL_AMBL数据集,将癌症影像档案馆的AMBL集合转化为标准深度学习数据集,包含88名患者、133个标注病灶(89个良性,44个恶性)。该资源填补了现有公开数据集中缺乏良性病灶标注的关键空白。训练过程中整合超过1,200名患者的BreastDCEDL数据集,验证了迁移学习的有效性,尽管主要标注仅限于原发肿瘤。数据集、模型及评估协议已公开,首次提供标准化基准,推动DCE-MRI病灶分类方法向临床部署迈进。

原文摘要 · Abstract (English)

Breast magnetic resonance imaging is a critical tool for cancer detection and treatment planning, but its clinical utility is hindered by poor specificity, leading to high false-positive rates and unnecessary biopsies. This study introduces a transformer-based framework for automated classification of breast lesions in dynamic contrast-enhanced MRI, addressing the challenge of distinguishing benign from malignant findings. We implemented a SegFormer architecture that achieved an AUC of 0.92 for lesion-level classification, with 100% sensitivity and 67% specificity at the patient level - potentially eliminating one-third of unnecessary biopsies without missing malignancies. The model quantifies malignant pixel distribution via semantic segmentation, producing interpretable spatial predictions that support clinical decision-making. To establish reproducible benchmarks, we curated BreastDCEDL_AMBL by transforming The Cancer Imaging Archive's AMBL collection into a standardized deep learning dataset with 88 patients and 133 annotated lesions (89 benign, 44 malignant). This resource addresses a key infrastructure gap, as existing public datasets lack benign lesion annotations, limiting benign-malignant classification research. Training incorporated an expanded cohort of over 1,200 patients through integration with BreastDCEDL datasets, validating transfer learning approaches despite primary tumor-only annotations. Public release of the dataset, models, and evaluation protocols provides the first standardized benchmark for DCE-MRI lesion classification, enabling methodological advancement toward clinical deployment.

乳腺癌Transformer医学影像数据集

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