arXiv:2510.01498cs.CVcs.AI2025-10被引 1

用无对比CT生成血管影像并同步分割,提升诊断准确性。

AortaDiff: A Unified Multitask Diffusion Framework For Contrast-Free AAA Imaging

  • 统一框架同时生成图像和分割结果,共享编码解码器参数。
  • 图像峰值信噪比达25.61 dB,血栓分割Dice达0.53,优于对比模型。
  • 适合临床少标注数据场景,可减少对比剂使用与测量误差。

尽管增强型CT(CECT)是评估腹主动脉瘤(AAA)的标准方法,但碘对比剂存在肾毒性、过敏反应及环境危害等风险。为减少对比剂使用,现有深度学习方法尝试从非增强CT(NCCT)生成合成CECT。然而,多数采用先生成图像再分割的多阶段流程,导致误差累积且未能利用共有的解剖结构。为此,本文提出统一多任务扩散框架AortaDiff,直接从NCCT生成合成CECT,并同步分割主动脉腔和血栓。该方法融合条件扩散模型与多任务学习,实现图像生成与分割的端到端联合优化。不同于以往多任务扩散模型,本方法无需初始预测,共享编码器与解码器参数,并采用半监督训练策略,可处理真实临床数据中常见的标注缺失问题。在264例患者数据上评估,其图像合成PSNR达25.61 dB(单任务模型为23.80 dB),腔体分割Dice提升至0.89(原为0.87),血栓分割Dice达0.53(原为0.48)。分割精度提升使腔径测量均方误差降至4.19 mm(原5.78 mm),血栓面积误差降低至33.85%(原41.45%)。代码已开源。

原文摘要 · Abstract (English)

While contrast-enhanced CT (CECT) is standard for assessing abdominal aortic aneurysms (AAA), the required iodinated contrast agents pose significant risks, including nephrotoxicity, patient allergies, and environmental harm. To reduce contrast agent use, recent deep learning methods have focused on generating synthetic CECT from non-contrast CT (NCCT) scans. However, most adopt a multi-stage pipeline that first generates images and then performs segmentation, which leads to error accumulation and fails to leverage shared semantic and anatomical structures. To address this, we propose a unified deep learning framework that generates synthetic CECT images from NCCT scans while simultaneously segmenting the aortic lumen and thrombus. Our approach integrates conditional diffusion models (CDM) with multi-task learning, enabling end-to-end joint optimization of image synthesis and anatomical segmentation. Unlike previous multitask diffusion models, our approach requires no initial predictions (e.g., a coarse segmentation mask), shares both encoder and decoder parameters across tasks, and employs a semi-supervised training strategy to learn from scans with missing segmentation labels, a common constraint in real-world clinical data. We evaluated our method on a cohort of 264 patients, where it consistently outperformed state-of-the-art single-task and multi-stage models. For image synthesis, our model achieved a PSNR of 25.61 dB, compared to 23.80 dB from a single-task CDM. For anatomical segmentation, it improved the lumen Dice score to 0.89 from 0.87 and the challenging thrombus Dice score to 0.53 from 0.48 (nnU-Net). These segmentation enhancements led to more accurate clinical measurements, reducing the lumen diameter MAE to 4.19 mm from 5.78 mm and the thrombus area error to 33.85% from 41.45% when compared to nnU-Net. Code is available at https://github.com/yuxuanou623/AortaDiff.git.

医学影像扩散模型多任务学习无对比成像

Thank you to arXiv for use of its open access interoperability. PaperDance 不是 arXiv 官方产品;中文卡片由大模型生成,请以原文为准。