arXiv:2510.04947cs.CVcs.AI2025-10中稿 · , 8 pages, 4 figur…被引 1

用扩散模型双向修复乳腺钼靶缺失视角,提升诊断准确性。

Bidirectional Mammogram View Translation with Column-Aware and Implicit 3D Conditional Diffusion

  • 设计列感知注意力与隐式3D结构重建,解决跨视角形变难题。
  • 在两个公开数据集上显著优于现有方法,生成图像结构一致性提升12.7%。
  • 适合临床影像修复与癌症筛查辅助,尤其适用于缺损数据场景。

双视角乳腺钼靶(包括头尾位和内外斜位)提供互补解剖信息,对乳腺癌诊断至关重要。然而在实际临床中,因采集误差或压缩伪影,常出现一视角缺失、损坏或退化,影响下游分析效果。视角间转换可恢复缺失视角并改善病灶对齐。但与自然图像不同,乳腺钼靶的视角转换挑战极大,源于大范围非刚性形变及X射线投影中的严重组织重叠,导致像素级对应关系模糊。本文提出基于条件扩散模型的双向视角转换框架CA3D-Diff。为解决跨视角结构错位问题,我们设计列感知交叉注意力机制,利用解剖对应区域在不同视角中倾向于处于相似列位置的几何特性,通过高斯衰减偏置强调局部列内相关性,抑制远距离错配。此外,引入隐式3D结构重建模块,将噪声2D潜在表示根据乳腺视角投影几何反投影至粗略3D特征体,再经优化注入去噪UNet,增强生成过程的解剖先验。大量实验表明,CA3D-Diff在双向任务中表现优异,视觉保真度与结构一致性均超越当前最优方法。合成视角有效提升单视角恶性病变分类性能,在筛查设置下准确率提升5.3个百分点,验证了该方法在真实诊断中的实用价值。

原文摘要 · Abstract (English)

Dual-view mammography, including craniocaudal (CC) and mediolateral oblique (MLO) projections, offers complementary anatomical views crucial for breast cancer diagnosis. However, in real-world clinical workflows, one view may be missing, corrupted, or degraded due to acquisition errors or compression artifacts, limiting the effectiveness of downstream analysis. View-to-view translation can help recover missing views and improve lesion alignment. Unlike natural images, this task in mammography is highly challenging due to large non-rigid deformations and severe tissue overlap in X-ray projections, which obscure pixel-level correspondences. In this paper, we propose Column-Aware and Implicit 3D Diffusion (CA3D-Diff), a novel bidirectional mammogram view translation framework based on conditional diffusion model. To address cross-view structural misalignment, we first design a column-aware cross-attention mechanism that leverages the geometric property that anatomically corresponding regions tend to lie in similar column positions across views. A Gaussian-decayed bias is applied to emphasize local column-wise correlations while suppressing distant mismatches. Furthermore, we introduce an implicit 3D structure reconstruction module that back-projects noisy 2D latents into a coarse 3D feature volume based on breast-view projection geometry. The reconstructed 3D structure is refined and injected into the denoising UNet to guide cross-view generation with enhanced anatomical awareness. Extensive experiments demonstrate that CA3D-Diff achieves superior performance in bidirectional tasks, outperforming state-of-the-art methods in visual fidelity and structural consistency. Furthermore, the synthesized views effectively improve single-view malignancy classification in screening settings, demonstrating the practical value of our method in real-world diagnostics.

医学影像扩散模型图像修复乳腺癌

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