用深度学习自动诊断眼源性异常头位并补全缺失病历数据。
Ocular-Induced Abnormal Head Posture: Diagnosis and Missing Data Imputation
- 融合眼点、头位和临床特征,实现可解释的自动诊断。
- 诊断准确率96.9%-99.0%,连续变量误差MAE低于0.2。
- 支持复杂病历缺失场景,适合临床智能辅助系统使用。
眼源性异常头位(AHP)是斜视等眼位不正导致的代偿机制,可减轻复视并维持双眼视觉。早期诊断能降低并发症风险,但现有评估多依赖主观判断,且常面临病历不全问题。本研究提出两个互补的深度学习框架:首先,AHP-CADNet 是一种多层级注意力融合模型,整合眼点、头位特征与结构化临床属性,实现可解释的自动诊断;其次,基于课程学习的填补框架,通过逐步利用结构化变量与非结构化临床记录,提升在真实数据条件下的诊断鲁棒性。在 PoseGaze-AHP 数据集上的评估显示,AHP-CADNet 在分类任务中准确率达 96.9%-99.0%,连续变量预测的 MAE 为 0.103-0.199,R² 超过 0.93;填补框架在所有临床变量上准确率 93.46%-99.78%(使用 PubMedBERT),结合临床依赖建模显著提升效果(p < 0.001)。结果验证了两框架在临床环境中的有效性。
原文摘要 · Abstract (English)
Ocular-induced abnormal head posture (AHP) is a compensatory mechanism that arises from ocular misalignment conditions, such as strabismus, enabling patients to reduce diplopia and preserve binocular vision. Early diagnosis minimizes morbidity and secondary complications such as facial asymmetry; however, current clinical assessments remain largely subjective and are further complicated by incomplete medical records. This study addresses both challenges through two complementary deep learning frameworks. First, AHP-CADNet is a multi-level attention fusion framework for automated diagnosis that integrates ocular landmarks, head pose features, and structured clinical attributes to generate interpretable predictions. Second, a curriculum learning-based imputation framework is designed to mitigate missing data by progressively leveraging structured variables and unstructured clinical notes to enhance diagnostic robustness under realistic data conditions. Evaluation on the PoseGaze-AHP dataset demonstrates robust diagnostic performance. AHP-CADNet achieves 96.9-99.0 percent accuracy across classification tasks and low prediction errors for continuous variables, with MAE ranging from 0.103 to 0.199 and R2 exceeding 0.93. The imputation framework maintains high accuracy across all clinical variables (93.46-99.78 percent with PubMedBERT), with clinical dependency modeling yielding significant improvements (p < 0.001). These findings confirm the effectiveness of both frameworks for automated diagnosis and recovery from missing data in clinical settings.
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