arXiv:2510.06283eess.IVcs.AI2025-10

用生成错误图增强记忆,让模型不断学新病灶也不忘旧知识。

SER-Diff: Synthetic Error Replay Diffusion for Incremental Brain Tumor Segmentation

  • 用冻结的扩散模型生成历史任务的错误图,作为增量学习中的回放数据。
  • 在BraTS2020-2023上达到95.8%、94.9%、94.6%的最高Dice分数。
  • 无需额外存储或生成数据,适合医疗影像持续学习场景。

增量脑肿瘤分割对需适应不断变化临床数据集的模型至关重要,但灾难性遗忘仍是主要障碍。现有基于知识蒸馏的增量学习框架虽部分缓解遗忘,却依赖生成回放或辅助存储。扩散模型在精修肿瘤分割方面表现优异,但尚未用于增量学习。本文提出首个融合扩散模型精修与增量学习的框架SER-Diff。该方法利用冻结的教师扩散模型生成过往任务的合成误差图,并在新任务训练时回放。通过结合新数据的Dice损失与回放误差的知识蒸馏损失,兼顾适应性与知识保留。在BraTS2020、BraTS2021和BraTS2023上的实验表明,SER-Diff持续优于现有方法,分别取得95.8%、94.9%、94.6%的最高Dice分数,以及4.4 mm、4.7 mm、4.9 mm的最低HD95值,证明其不仅能有效缓解遗忘,还能在演化数据集上实现更准确、解剖结构更一致的分割结果。

原文摘要 · Abstract (English)

Incremental brain tumor segmentation is critical for models that must adapt to evolving clinical datasets without retraining on all prior data. However, catastrophic forgetting, where models lose previously acquired knowledge, remains a major obstacle. Recent incremental learning frameworks with knowledge distillation partially mitigate forgetting but rely heavily on generative replay or auxiliary storage. Meanwhile, diffusion models have proven effective for refining tumor segmentations, but have not been explored in incremental learning contexts. We propose Synthetic Error Replay Diffusion (SER-Diff), the first framework that unifies diffusion-based refinement with incremental learning. SER-Diff leverages a frozen teacher diffusion model to generate synthetic error maps from past tasks, which are replayed during training on new tasks. A dual-loss formulation combining Dice loss for new data and knowledge distillation loss for replayed errors ensures both adaptability and retention. Experiments on BraTS2020, BraTS2021, and BraTS2023 demonstrate that SER-Diff consistently outperforms prior methods. It achieves the highest Dice scores of 95.8\%, 94.9\%, and 94.6\%, along with the lowest HD95 values of 4.4 mm, 4.7 mm, and 4.9 mm, respectively. These results indicate that SER-Diff not only mitigates catastrophic forgetting but also delivers more accurate and anatomically coherent segmentations across evolving datasets.

增量学习扩散模型医学图像分割

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