首次系统研究医学大模型领域微调，发现仅改变小部分参数空间

Large Language Models (LLMs) fine-tuned for specific domains exhibit strong performance; however, the underlying mechanisms by which this fine-tuning reshapes their parametric space are not well understood. Prior works primarily focus on auto-regressive or general-purpose instruct models, leaving domain-specialised LLMs under-explored. We present the first systematic study of domain-specific fine-tuning in large medical language models. Our analysis reveals that fine-tuning modifies only a small subset of the representational subspace, essentially preserving the pre-trained model's representation. To interpret these changes in subspaces, we propose tuning vectors, a novel framework inspired by task vectors, which explicitly capture the directional parameter shifts induced by fine-tuning. We demonstrate that these vectors are critical for enhancing both instruction-following and generation quality. Furthermore, combining tuning vectors across different domains yields improved generalisation. Upon closer inspection of directional alignment, we find these vectors primarily write new directional information into the MLP layers of the model, while amplifying existing directions in attention heads. Our findings offer new insights into LLM adaptation and provide a general, interpretable framework for analysing specialisation in large language models.