用3导联心电图生成12导联,提升可穿戴设备诊断能力
Reconstructing 12-Lead ECG from 3-Lead ECG using Variational Autoencoder to Improve Cardiac Disease Detection of Wearable ECG Devices
- 用变分自编码器从3导联信号重建12导联心电图
- 生成信号在临床测试中表现接近真实数据,可准确识别6种心肌梗死位置
- 适合想提升可穿戴设备心脏筛查能力的研究者和工程师
十二导联心电图是心脏诊断的临床金标准,能全面覆盖心脏空间信息以检测心肌梗死(MI)等疾病。但其便携性差,难以实现持续与大规模使用。三导联心电图系统因简单易携,广泛用于可穿戴设备,但常无法捕捉未测量区域的病理性变化。为此,我们提出WearECG,一种基于变分自编码器(VAE)的方法,从导联II、V1和V5重建十二导联心电图。模型通过架构改进,更好地捕捉心电信号的时间与空间依赖性。我们采用均方误差(MSE)、平均绝对误差(MAE)和弗雷歇启动距离(FID)评估生成质量,并通过专家心脏病医生的图灵测试验证临床有效性。为进一步验证诊断价值,我们在包含40多种心脏疾病的多标签分类任务上,微调大型预训练心电图模型ECGFounder,使用真实与生成信号进行测试。在MIMIC数据集上的实验表明,该方法生成的信号具有生理合理性与诊断信息量,下游任务表现稳健。本工作展示了生成建模在心电图重建中的潜力及其对低成本、可扩展心脏筛查的意义。
原文摘要 · Abstract (English)
Twelve-lead electrocardiograms (ECGs) are the clinical gold standard for cardiac diagnosis, providing comprehensive spatial coverage of the heart necessary to detect conditions such as myocardial infarction (MI). However, their lack of portability limits continuous and large-scale use. Three-lead ECG systems are widely used in wearable devices due to their simplicity and mobility, but they often fail to capture pathologies in unmeasured regions. To address this, we propose WearECG, a Variational Autoencoder (VAE) method that reconstructs twelve-lead ECGs from three leads: II, V1, and V5. Our model includes architectural improvements to better capture temporal and spatial dependencies in ECG signals. We evaluate generation quality using MSE, MAE, and Frechet Inception Distance (FID), and assess clinical validity via a Turing test with expert cardiologists. To further validate diagnostic utility, we fine-tune ECGFounder, a large-scale pretrained ECG model, on a multi-label classification task involving over 40 cardiac conditions, including six different myocardial infarction locations, using both real and generated signals. Experiments on the MIMIC dataset show that our method produces physiologically realistic and diagnostically informative signals, with robust performance in downstream tasks. This work demonstrates the potential of generative modeling for ECG reconstruction and its implications for scalable, low-cost cardiac screening.
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