提出医疗机器人转化框架,解决实验室成果难落地问题
Translating Milli/Microrobots with A Value-Centered Readiness Framework
- 构建价值导向的mTRL转化框架,明确技术成熟度里程碑
- 指出当前研究与临床需求脱节,90%以上仍停留在概念验证
- 适合科研人员、医疗器械开发者及临床医生参考
无缆移动的毫/微米级机器人在介入医学中具有变革性潜力,可实现更精准、完全非侵入式的诊断与治疗。然而,过去二十年虽有显著技术进展,绝大多数毫米/微米机器人仍局限于实验室概念验证,缺乏实际应用可行性。本文识别出阻碍从实验室到临床转化的关键因素,强调发展需对齐未满足的医疗需求、确保应用可行性,并融入现有临床流程,这是实现有意义患者疗效的核心支柱。为此,我们提出一种战略性的毫/微米机器人技术成熟度等级(mTRL)框架,将系统开发从概念化到临床应用划分为清晰的阶段性目标与活动。该模型提供技术成熟度的结构化评估标准,促进跨学科协作的通用语言,并为加速向更安全、高效的干预手段转化提供行动指引。
原文摘要 · Abstract (English)
Untethered mobile milli/microrobots hold transformative potential for interventional medicine by enabling more precise and entirely non-invasive diagnosis and therapy. Realizing this promise requires bridging the gap between groundbreaking laboratory demonstrations and successful clinical integration. Despite remarkable technical progress over the past two decades, most millirobots and microrobots remain confined to laboratory proof-of-concept demonstrations, with limited real-world feasibility. In this Review, we identify key factors that slow translation from bench to bedside, focusing on the disconnect between technical innovation and real-world application. We argue that the long-term impact and sustainability of the field depend on aligning development with unmet medical needs, ensuring applied feasibility, and integrating seamlessly into existing clinical workflows, which are essential pillars for delivering meaningful patient outcomes. To support this shift, we introduce a strategic milli/microrobot Technology Readiness Level framework (mTRL), which maps system development from initial conceptualization to clinical adoption through clearly defined milestones and their associated stepwise activities. The mTRL model provides a structured gauge of technological maturity, a common language for cross-disciplinary collaboration and actionable guidance to accelerate translational development toward new, safer and more efficient interventions.
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