用自监督方法从噪声OCT图像中恢复清晰图像，无需配对数据。

Optical Coherence Tomography (OCT) is a widely used non-invasive imaging technique that provides detailed three-dimensional views of the retina, which are essential for the early and accurate diagnosis of ocular diseases. Consequently, OCT image analysis and processing have emerged as key research areas in biomedical imaging. However, acquiring paired datasets of clean and real-world noisy OCT images for supervised denoising models remains a formidable challenge due to intrinsic speckle noise and practical constraints in clinical imaging environments. To address these issues, we propose SDPA++: A General Framework for Self-Supervised Denoising with Patch Aggregation. Our novel approach leverages only noisy OCT images by first generating pseudo-ground-truth images through self-fusion and self-supervised denoising. These refined images then serve as targets to train an ensemble of denoising models using a patch-based strategy that effectively enhances image clarity. Performance improvements are validated via metrics such as Contrast-to-Noise Ratio (CNR), Mean Square Ratio (MSR), Texture Preservation (TP), and Edge Preservation (EP) on the real-world dataset from the IEEE SPS Video and Image Processing Cup. Notably, the VIP Cup dataset contains only real-world noisy OCT images without clean references, highlighting our method's potential for improving image quality and diagnostic outcomes in clinical practice.