arXiv:2510.17278cs.CV2025-10

提出新框架,提升白细胞分割分类准确率与可解释性。

SG-CLDFF: A Novel Framework for Automated White Blood Cell Classification and Segmentation

  • 用显著性图引导预处理,融合多尺度深层特征
  • 在多个数据集上分割和分类指标均优于主流模型
  • 适合临床场景,结果可可视化解释

显微图像中白细胞的精确分割与分类对血液病诊断至关重要,但受染色差异、复杂背景和类别不平衡影响仍具挑战。本文提出一种显著性引导跨层深度特征融合框架(SG-CLDFF),通过显著性先验突出候选白细胞区域并指导特征提取。采用轻量级混合骨干网络(EfficientSwin风格)生成多分辨率表示,并通过受ResNeXt-CC启发的跨层融合模块保留浅层与深层互补信息。网络以多任务方式训练,同时优化分割头与分类头,使用类感知加权损失与显著性对齐正则化缓解类别不平衡并抑制背景激活。通过Grad-CAM可视化与显著性一致性检验增强可解释性,支持区域级决策审查。在标准公开数据集BCCD、LISC、ALL-IDB上验证,相较强基线(CNN与Transformer)在IoU、F1及分类准确率上持续提升。消融实验表明显著性预处理与跨层融合各自贡献显著。该框架为临床工作流中更可靠的自动化白细胞分析提供可行路径。

原文摘要 · Abstract (English)

Accurate segmentation and classification of white blood cells (WBCs) in microscopic images are essential for diagnosis and monitoring of many hematological disorders, yet remain challenging due to staining variability, complex backgrounds, and class imbalance. In this paper, we introduce a novel Saliency-Guided Cross-Layer Deep Feature Fusion framework (SG-CLDFF) that tightly integrates saliency-driven preprocessing with multi-scale deep feature aggregation to improve both robustness and interpretability for WBC analysis. SG-CLDFF first computes saliency priors to highlight candidate WBC regions and guide subsequent feature extraction. A lightweight hybrid backbone (EfficientSwin-style) produces multi-resolution representations, which are fused by a ResNeXt-CC-inspired cross-layer fusion module to preserve complementary information from shallow and deep layers. The network is trained in a multi-task setup with concurrent segmentation and cell-type classification heads, using class-aware weighted losses and saliency-alignment regularization to mitigate imbalance and suppress background activation. Interpretability is enforced through Grad-CAM visualizations and saliency consistency checks, allowing model decisions to be inspected at the regional level. We validate the framework on standard public benchmarks (BCCD, LISC, ALL-IDB), reporting consistent gains in IoU, F1, and classification accuracy compared to strong CNN and transformer baselines. An ablation study also demonstrates the individual contributions of saliency preprocessing and cross-layer fusion. SG-CLDFF offers a practical and explainable path toward more reliable automated WBC analysis in clinical workflows.

医学图像白细胞分割可解释性

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