用量子生成对抗网络合成生物制造数据,缓解实验数据不足问题
Quantum Synthetic Data Generation for Industrial Bioprocess Monitoring
- 用参数化量子电路构建生成器,通过量子Wasserstein GAN生成时间序列数据
- 合成数据与真实光学密度数据在时序动态上高度一致,验证了高保真度
- 适合需要高效建模的工业生物过程监控与软传感器设计场景
生物制造中数据稀缺和稀疏性给模型构建、过程监控与优化带来挑战。本文提出使用带有梯度惩罚的量子Wasserstein生成对抗网络(QWGAN-GP)生成工业相关过程的合成时间序列数据。生成器采用参数化量子电路(PQC)。该方法在过程监控、建模、预测和优化方面具有潜力,可减少对稀缺实验数据的依赖。结果表明,合成数据能有效捕捉真实生物过程的时间动态特征,重点针对光学密度(用于干生物质估算的关键指标),其生成数据与历史实验数据具有高保真度。量子计算与机器学习的融合为计算密集型领域中的数据分析与生成开辟新路径,适用于提升软传感器预测精度或实现预测控制。
原文摘要 · Abstract (English)
Data scarcity and sparsity in bio-manufacturing poses challenges for accurate model development, process monitoring, and optimization. We aim to replicate and capture the complex dynamics of industrial bioprocesses by proposing the use of a Quantum Wasserstein Generative Adversarial Network with Gradient Penalty (QWGAN-GP) to generate synthetic time series data for industrially relevant processes. The generator within our GAN is comprised of a Parameterized Quantum Circuit (PQC). This methodology offers potential advantages in process monitoring, modeling, forecasting, and optimization, enabling more efficient bioprocess management by reducing the dependence on scarce experimental data. Our results demonstrate acceptable performance in capturing the temporal dynamics of real bioprocess data. We focus on Optical Density, a key measurement for Dry Biomass estimation. The data generated showed high fidelity to the actual historical experimental data. This intersection of quantum computing and machine learning has opened new frontiers in data analysis and generation, particularly in computationally intensive fields, for use cases such as increasing prediction accuracy for soft sensor design or for use in predictive control.
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