解决治疗决策优化中的胜者诅咒，提升真实效果可信度

There has been a surge of recent interest in automatically learning policies to target treatment decisions based on rich individual covariates. In addition, practitioners want confidence that the learned policy has better performance than the incumbent policy according to downstream policy evaluation. However, due to the winner's curse -- an issue where the policy optimization procedure exploits prediction errors rather than finding actual improvements -- predicted performance improvements are often not substantiated by downstream policy evaluation. To address this challenge, we propose a novel strategy called inference-aware policy optimization, which modifies policy optimization to account for how the policy will be evaluated downstream. Specifically, it optimizes not only for the estimated objective value, but also for the chances that the estimate of the policy's improvement passes a significance test during downstream policy evaluation. We mathematically characterize the Pareto frontier of policies according to the tradeoff of these two goals. Based on our characterization, we design a policy optimization algorithm that estimates the Pareto frontier using machine learning models; then, the decision-maker can select the policy that optimizes their desired tradeoff, after which policy evaluation can be performed on the test set as usual. Finally, we perform simulations to illustrate the effectiveness of our methodology.