基于脑电活动动态推断行为阶段特异的神经连接图,兼具预测与可解释性。
BACE: Behavior-Adaptive Connectivity Estimation for Interpretable Graphs of Neural Dynamics
- 通过区域时序编码和分阶段可学习邻接矩阵,从多区域脑电数据直接建模连接关系。
- 在合成数据上准确恢复真实有向连接,在真实人类数据中揭示行为阶段特异的网络重配置。
- 适合研究神经动力学与行为关联的科研人员,尤其关注动态脑网络分析者。
理解分布式脑区如何协同产生行为,需要兼具预测力与可解释性的模型。本文提出行为自适应连接估计(BACE),一种端到端框架,直接从多区域颅内局部场电位(LFP)中学习行为阶段特异的有向区域间连接。BACE通过每区域的时间编码聚合多个微电极信号,采用针对每个行为阶段的可学习邻接矩阵,并以预测目标进行训练。在具有已知图结构的合成多变量时间序列上,BACE准确恢复真实有向交互,且预测性能与当前最优基线相当。应用于人类皮层下8个区域在提示伸手任务中同步记录的LFP数据,BACE为每个试次内的行为阶段生成明确的连接矩阵。结果表明,不同行为阶段的网络影响模式存在显著重构,提供简洁可解释的邻接矩阵,用于跨阶段比较网络组织。通过将预测成功与显式连接估计关联,BACE为生成关于皮层下区域行为期间动态协调的数据驱动假说提供了实用工具。
原文摘要 · Abstract (English)
Understanding how distributed brain regions coordinate to produce behavior requires models that are both predictive and interpretable. We introduce Behavior-Adaptive Connectivity Estimation (BACE), an end-to-end framework that learns phase-specific, directed inter-regional connectivity directly from multi-region intracranial local field potentials (LFP). BACE aggregates many micro-contacts within each anatomical region via per-region temporal encoders, applies a learnable adjacency specific to each behavioral phase, and is trained on a forecasting objective. On synthetic multivariate time series with known graphs, BACE accurately recovers ground-truth directed interactions while achieving forecasting performance comparable to state-of-the-art baselines. Applied to human subcortical LFP recorded simultaneously from eight regions during a cued reaching task, BACE yields an explicit connectivity matrix for each within-trial behavioral phase. The resulting behavioral phase-specific graphs reveal behavior-aligned reconfiguration of inter-regional influence and provide compact, interpretable adjacency matrices for comparing network organization across behavioral phases. By linking predictive success to explicit connectivity estimates, BACE offers a practical tool for generating data-driven hypotheses about the dynamic coordination of subcortical regions during behavior.
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