arXiv:2511.04539q-bio.NCcs.LG2025-11中稿 · ICML

用几何引导的生成模型,从脑功能图中学习紧凑表示并合成新图

Geometry-Guided Generative Representation for Functional Brain Graphs

  • 用图Transformer自编码器学习脑图低维几何结构
  • 无监督训练下准确区分认知状态,解码视觉刺激表现优异
  • 适合脑科学与生成模型交叉研究者

在神经网络科学中,功能脑系统常通过独立但相关的图论或谱描述符表征,忽略了这些属性在个体和条件间协变及部分重叠。我们假设密集加权的功能连接图位于一个低维潜在几何空间中,该空间上拓扑与谱结构在群体水平平滑变化。尽管基于图的深度学习为建模脑连通组提供了强大框架,但监督方法受限于标注数据稀缺;现有无监督图表示方法通常关注节点级嵌入,难以捕捉紧凑的图级表示以保留密集功能连通组信息。为此,我们采用图Transformer自编码器学习紧凑脑图表示,利用领域特定的对齐功能梯度几何作为归纳偏置引导学习。尽管完全无监督训练,该方法仍能有效区分认知状态,并实现视觉刺激解码,结合神经动态后性能进一步提升。同时,为生成合成脑图,我们在学习到的潜在表示上拟合扩散模型,并将样本解码回密集连通组。

原文摘要 · Abstract (English)

In network neuroscience, functional brain systems are often characterized using separate yet related graph-theoretic or spectral descriptors, overlooking how these properties covary and partially overlap across individuals and conditions. We anticipate that dense, weighted functional connectivity graphs lie on a low-dimensional latent geometry along which both topological and spectral structures vary smoothly at the population level. Although graph-based deep learning offers a powerful framework for modeling these brain connectomes, supervised approaches are constrained by the limited availability of labeled data. Existing unsupervised graph representation methods also typically focus on node-level embeddings, which are limited in capturing compact graph-level representations that preserve information from dense functional connectomes. To address these gaps, we learn compact brain graph representations using a graph transformer autoencoder, where domain-specific, aligned functional gradient geometry provides an inductive bias to guide learning. Despite being trained in a fully unsupervised manner, our approach meaningfully separates cognitive states and enables decoding of visual stimuli, with performance further improved by incorporating neural dynamics. In parallel, to enable generation of synthetic brain graphs, we fit a diffusion model to the learned latent representation and decode samples back to dense connectomes.

脑图建模生成模型图神经网络

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