研究了磁共振成像参数与软骨力学性质关系的不确定性对有限元模型的影响。
Sensitivity of Finite Element Models to Relationship Between T2 Relaxation and Modulus in Articular Cartilage
- 通过调整T2与动态模量的线性关系斜率和截距，测试模型敏感性。
- 模量变化导致最大应力应变值出现显著百分比改变，斜率变动影响可忽略。
- 支持在个体化模型中采用生理范围内的模量值以提高准确性。
将关节软骨材料属性与定量磁共振成像生物标志物相关联，是构建生物逼真有限元模型的有效方法。然而，影像生物标志物（如T2）与材料属性（如动态模量）之间的个体差异关系尚不明确。为评估有限元模型对这种不确定性的敏感性，我们改变了用于定义软骨属性的线性T2-动态模量关系的斜率和截距。结果显示，模量的调整导致计算所得最大1%应力和应变值发生显著百分比变化，而斜率调节的影响则可忽略不计，这表明在个体化模型中使用生理相关的模量范围是合理的。
原文摘要 · Abstract (English)
Correlating articular cartilage material properties to quantitative magnetic resonance imaging biomarkers is a powerful approach to biofidelic finite element models. However, subject-specific relationships between imaging biomarkers such as T2 and material properties like dynamic modulus are uncertain. To evaluate the sensitivity of finite element models to this uncertainty, we shifted the slope and intercept of a linear T2-dynamic modulus relationship used to define cartilage properties. Modulus shifts led to notable percent changes in the top 1% of calculated stress and strain while modulating slope had a negligible impact, together supporting the use of physiologically relevant moduli ranges in subject-specific models.
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