用条件生成模型提升低视角CT图像质量,减少辐射损伤。
PoCGM: Poisson-Conditioned Generative Model for Sparse-View CT Reconstruction
- 将泊松流生成模型改造为条件框架,以稀疏投影数据为引导重建
- 相比基线方法,显著抑制伪影并保留更多结构细节
- 适合低剂量和高速成像场景,临床应用潜力大
在计算机断层扫描(CT)中,减少投影视图数量是降低辐射暴露和提升时间分辨率的有效策略。然而,这常导致严重的混叠伪影和结构细节丢失,给临床应用带来挑战。受泊松流生成模型(PFGM++)在自然图像生成中的成功启发,本文提出一种泊松条件生成模型(PoCGM),用于解决稀疏视图CT重建难题。由于PFGM++最初设计为无条件生成,无法直接应用于需输入条件的医学影像任务,因此PoCGM通过在训练与采样阶段引入稀疏视图数据作为条件,将PFGM++重构为条件生成框架。该模型建模了基于稀疏观测的全视图重建后验分布,有效抑制伪影并保留精细结构。定性与定量评估表明,PoCGM优于现有基线方法,在伪影抑制、细节保持方面表现更优,并在剂量敏感和时间关键的成像场景中展现出可靠性能。
原文摘要 · Abstract (English)
In computed tomography (CT), reducing the number of projection views is an effective strategy to lower radiation exposure and/or improve temporal resolution. However, this often results in severe aliasing artifacts and loss of structural details in reconstructed images, posing significant challenges for clinical applications. Inspired by the success of the Poisson Flow Generative Model (PFGM++) in natural image generation, we propose a PoCGM (Poisson-Conditioned Generative Model) to address the challenges of sparse-view CT reconstruction. Since PFGM++ was originally designed for unconditional generation, it lacks direct applicability to medical imaging tasks that require integrating conditional inputs. To overcome this limitation, the PoCGM reformulates PFGM++ into a conditional generative framework by incorporating sparse-view data as guidance during both training and sampling phases. By modeling the posterior distribution of full-view reconstructions conditioned on sparse observations, PoCGM effectively suppresses artifacts while preserving fine structural details. Qualitative and quantitative evaluations demonstrate that PoCGM outperforms the baselines, achieving improved artifact suppression, enhanced detail preservation, and reliable performance in dose-sensitive and time-critical imaging scenarios.
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