arXiv:2511.17604cs.LGcs.AI2025-11AAAI被引 1

提出分层图注意力模型,更真实模拟大脑信息处理机制。

BrainHGT: A Hierarchical Graph Transformer for Interpretable Brain Network Analysis

  • 设计长短程并行注意力,区分局部与远程连接模式。
  • 通过先验引导聚类识别脑功能模块,提升可解释性。
  • 在疾病识别中表现优异,适合神经科学与医学研究者。

图变压器在脑网络分析中展现出巨大潜力,因其能建模图结构和复杂节点关系。然而,现有方法通常将大脑视为平面网络,忽略其模块化结构,且注意力机制对所有脑区连接一视同仁,未考虑距离相关的连接模式。事实上,大脑信息处理是分层过程,涉及局部与远距离脑区互动、脑区与子功能模块间互动,以及功能模块间的互动。这种分层机制使大脑能高效整合局部计算与全局信息流,支持复杂认知功能。为此,我们提出BrainHGT,一种模拟大脑从局部区域到全局社区信息处理的分层图变压器。具体而言,设计新型长短程并行注意力编码器,分别处理密集局部连接与稀疏长程连接,有效缓解过度全局化问题。为进一步捕捉大脑模块化架构,设计先验引导聚类模块,利用交叉注意力将脑区分组为功能社区,并结合神经解剖学先验指导聚类过程,提升生物学合理性与可解释性。实验结果表明,该方法显著提升疾病识别性能,能可靠捕捉脑的亚功能模块,验证了其可解释性。

原文摘要 · Abstract (English)

Graph Transformer shows remarkable potential in brain network analysis due to its ability to model graph structures and complex node relationships. Most existing methods typically model the brain as a flat network, ignoring its modular structure, and their attention mechanisms treat all brain region connections equally, ignoring distance-related node connection patterns. However, brain information processing is a hierarchical process that involves local and long-range interactions between brain regions, interactions between regions and sub-functional modules, and interactions among functional modules themselves. This hierarchical interaction mechanism enables the brain to efficiently integrate local computations and global information flow, supporting the execution of complex cognitive functions. To address this issue, we propose BrainHGT, a hierarchical Graph Transformer that simulates the brain's natural information processing from local regions to global communities. Specifically, we design a novel long-short range attention encoder that utilizes parallel pathways to handle dense local interactions and sparse long-range connections, thereby effectively alleviating the over-globalizing issue. To further capture the brain's modular architecture, we designe a prior-guided clustering module that utilizes a cross-attention mechanism to group brain regions into functional communities and leverage neuroanatomical prior to guide the clustering process, thereby improving the biological plausibility and interpretability. Experimental results indicate that our proposed method significantly improves performance of disease identification, and can reliably capture the sub-functional modules of the brain, demonstrating its interpretability.

脑网络分析图神经网络可解释性

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