arXiv:2511.17606cs.LGcs.AI2025-11AAAI被引 2

用能量模型高效生成真实神经元活动,提升脑机接口性能。

Energy-based Autoregressive Generation for Neural Population Dynamics

论文配图:Energy-based Autoregressive Generation for Neural Population Dynamics
图 1 · 摘自论文原文
  • 基于能量函数的自回归框架,通过评分规则学习潜空间时序动态。
  • 在合成与真实数据上生成质量达顶尖水平,计算效率远超扩散模型。
  • 可泛化到未见行为场景,助力脑机接口解码精度提升。

理解大脑功能是神经科学的核心目标,对治疗干预和神经工程具有重要意义。计算建模为加速这一理解提供了定量框架,但面临计算效率与高保真度之间的根本权衡。为此,我们提出一种新型能量基自回归生成(EAG)框架,利用能量基Transformer通过严格恰当评分规则学习潜空间中的时序动态,实现高效生成并保持真实的群体与单神经元放电统计特性。在合成洛伦兹数据集及两个神经潜变量基准数据集(MC_Maze 和 Area2_bump)上的评估表明,EAG在生成质量上达到当前最优,且计算效率显著优于扩散类方法。除高性能外,条件生成应用展示了两项能力:泛化至未见行为情境,以及利用合成神经数据提升运动型脑机接口解码准确率。这些结果证明了能量基建模在神经群体动力学中的有效性,适用于神经科学研究与神经工程应用。代码已开源:https://github.com/NinglingGe/Energy-based-Autoregressive-Generation-for-Neural-Population-Dynamics。

原文摘要 · Abstract (English)

Understanding brain function represents a fundamental goal in neuroscience, with critical implications for therapeutic interventions and neural engineering applications. Computational modeling provides a quantitative framework for accelerating this understanding, but faces a fundamental trade-off between computational efficiency and high-fidelity modeling. To address this limitation, we introduce a novel Energy-based Autoregressive Generation (EAG) framework that employs an energy-based transformer learning temporal dynamics in latent space through strictly proper scoring rules, enabling efficient generation with realistic population and single-neuron spiking statistics. Evaluation on synthetic Lorenz datasets and two Neural Latents Benchmark datasets (MC_Maze and Area2_bump) demonstrates that EAG achieves state-of-the-art generation quality with substantial computational efficiency improvements, particularly over diffusion-based methods. Beyond optimal performance, conditional generation applications show two capabilities: generalizing to unseen behavioral contexts and improving motor brain-computer interface decoding accuracy using synthetic neural data. These results demonstrate the effectiveness of energy-based modeling for neural population dynamics with applications in neuroscience research and neural engineering. Code is available at https://github.com/NinglingGe/Energy-based-Autoregressive-Generation-for-Neural-Population-Dynamics.

神经动力学能量模型自回归生成脑机接口

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