arXiv:2511.18063cs.CVq-bio.TO2025-11

用轻量可解释AI辅助识别宫颈腺癌原位病变,提升早期筛查效率。

A Lightweight, Interpretable Deep Learning System for Automated Detection of Cervical Adenocarcinoma In Situ (AIS)

  • 基于EfficientNet-B3和焦点损失,处理数据不平衡问题。
  • 在CAISHI数据集上达F1-score 0.75,准确区分正常与异常腺体组织。
  • 热力图揭示癌变特征,适合临床辅助与资源匮乏地区使用。

宫颈腺癌原位病变(AIS)是一种关键的癌前病变,其病理诊断具有挑战性,早期发现对防止进展为浸润性腺癌至关重要。本研究构建了一个基于深度学习的虚拟病理助手,利用包含2240张专家标注H&E图像(1010张正常,1230张AIS)的CAISHI数据集,通过Macenko染色归一化与基于图像块的预处理增强形态学特征表示。采用类平衡采样与焦点损失训练EfficientNet-B3模型,以应对数据分布不均并强化难分类样本的学习。最终模型整体准确率为0.7323,异常类F1-score为0.75,正常类为0.71。Grad-CAM热力图呈现生物可解释的激活模式,突出核异型性和腺体拥挤等符合AIS形态学特征的区域。模型已部署于Gradio-based虚拟诊断助手。结果表明,轻量且可解释的AI系统在宫颈腺体病理分析中具有可行性,适用于筛查流程、医学教育及低资源环境。

原文摘要 · Abstract (English)

Cervical adenocarcinoma in situ (AIS) is a critical premalignant lesion whose accurate histopathological diagnosis is challenging. Early detection is essential to prevent progression to invasive cervical adenocarcinoma. In this study, we developed a deep learning-based virtual pathology assistant capable of distinguishing AIS from normal cervical gland histology using the CAISHI dataset, which contains 2240 expert-labeled H&E images (1010 normal and 1230 AIS). All images underwent Macenko stain normalization and patch-based preprocessing to enhance morphological feature representation. An EfficientNet-B3 convolutional neural network was trained using class-balanced sampling and focal loss to address dataset imbalance and emphasize difficult examples. The final model achieved an overall accuracy of 0.7323, with an F1-score of 0.75 for the Abnormal class and 0.71 for the Normal class. Grad-CAM heatmaps demonstrated biologically interpretable activation patterns, highlighting nuclear atypia and glandular crowding consistent with AIS morphology. The trained model was deployed in a Gradio-based virtual diagnostic assistant. These findings demonstrate the feasibility of lightweight, interpretable AI systems for cervical gland pathology, with potential applications in screening workflows, education, and low-resource settings.

宫颈癌筛查可解释AI轻量模型病理检测

Thank you to arXiv for use of its open access interoperability. PaperDance 不是 arXiv 官方产品;中文卡片由大模型生成,请以原文为准。