通过动态笔迹分析提升阿尔茨海默病早期筛查精度
A Fine Evaluation Method for Cube Copying Test for Early Detection of Alzheimer's Disease
- 基于动态笔迹特征提取，用BiLSTM-Attention模型实现细粒度评估
- 分类准确率达86.69%，显著优于传统0/1评分方法
- 适合关注认知障碍早期检测与个性化干预的研究者
背景：视觉空间认知功能受损是阿尔茨海默病（AD）最常见的早期临床表现。当蒙特利尔认知评估（MoCA）采用“0/1”二元法（通过/失败）评价立方体复制测试（CCT）时，受教育程度较低的老年人常得0分，导致评估结果严重偏差。为此，本研究提出一种基于动态笔迹特征提取的精细评估方法（DH-SCSM-BLA）。方法：使用团队自主开发的Cogni-CareV3.0软件采集CCT动态笔迹数据，提取分段笔迹的空间与运动特征，对非等维特征矩阵进行归一化处理，最终采用结合注意力机制的双向长短期记忆网络（BiLSTM-Attention）进行分类。结果：实验表明，该方法在分类准确率上显著优于同类研究，达到86.69%。立方体绘制能力得分在轻度认知障碍（MCI）患者与健康对照组、年龄及教育水平三方面均呈现显著规律性。发现所有认知任务得分（包括立方体绘制能力）均与年龄呈负相关，与教育水平呈显著正相关。结论：本研究提供了一种相对客观、全面的视觉空间认知障碍早期筛查与个性化干预评估方法。
原文摘要 · Abstract (English)
Background: Impairment of visual spatial cognitive function is the most common early clinical manifestation of Alzheimer's Disease (AD). When the Montreal Cognitive Assessment (MoCA) uses the "0/1" binary method ("pass/fail") to evaluate the visual spatial cognitive ability represented by the Cube Copying Test(CCT), the elder with less formal education generally score 0 point, resulting in serious bias in the evaluation results. Therefore, this study proposes a fine evaluation method for CCT based on dynamic handwriting feature extraction of DH-SCSM-BLA. method : The Cogni-CareV3.0 software independently developed by our team was used to collect dynamic handwriting data of CCT. Then, the spatial and motion features of segmented dynamic handwriting were extracted, and feature matrix with unequal dimensions were normalized. Finally, a bidirectional long short-term memory network model combined with attention mechanism (BiLSTM-Attention) was adopted for classification. Result: The experimental results showed that: The proposed method has significant superiority compared to similar studies, with a classification accuracy of 86.69%. The distribution of cube drawing ability scores has significant regularity for three aspects such as MCI patients and healthy control group, age, and levels of education. It was also found that score for each cognitive task including cube drawing ability score is negatively correlated with age. Score for each cognitive task including cube drawing ability score, but positively correlated with levels of education significantly. Conclusion: This study provides a relatively objective and comprehensive evaluation method for early screening and personalized intervention of visual spatial cognitive impairment.
Thank you to arXiv for use of its open access interoperability. PaperDance 不是 arXiv 官方产品；中文卡片由大模型生成，请以原文为准。