用内在坐标空间实现心脏电生理的几何无关算子学习,提升预测精度。
A unified framework for geometry-independent operator learning in cardiac electrophysiology simulations
- 在流形上定义内在坐标系,摆脱网格依赖与几何差异影响。
- 在心房和心室几何上均超越现有神经算子方法,准确预测激活时间图。
- 适用于心脏电生理与生物力学,适合复杂几何物理系统研究者。
在异质且不规则几何上学习神经算子仍是根本挑战,因现有方法通常依赖结构化离散或显式映射至共享参考域。本文提出统一框架,将学习问题重构于定义在底层流形上的内在坐标空间中。通过在共享坐标域中表达输入与输出,该框架使算子学习与网格离散及几何变化解耦,同时保留有意义的空间组织,并实现在原始几何上的忠实重建。我们在心脏电生理领域验证该框架,该场景因心脏几何间极端解剖差异而极具挑战。利用GPU加速模拟流水线,在多种患者特异性解剖结构上生成大规模高保真电生理模拟数据集,并训练定制化神经算子以预测全场局部激活时间图。所提方法在心房与心室几何上均优于现有神经算子。此外,该表示还可用于心脏生物力学(涉及体积变形)的算子学习,展示了其通用性。这些结果确立了内在坐标表示作为复杂物理系统中神经算子学习的原理性且可扩展路径。
原文摘要 · Abstract (English)
Learning neural operators on heterogeneous and irregular geometries remains a fundamental challenge, as existing approaches typically rely on structured discretisations or explicit mappings to a shared reference domain. We propose a unified framework for geometry-independent operator learning that reformulates the learning problem in an intrinsic coordinate space defined on the underlying manifold. By expressing both inputs and outputs in this shared coordinate domain, the framework decouples operator learning from mesh discretisation and geometric variability, while preserving meaningful spatial organisation and enabling faithful reconstruction on the original geometry. We demonstrate the framework on cardiac electrophysiology, a particularly challenging setting due to extreme anatomical variability across heart geometries. Leveraging a GPU-accelerated simulation pipeline, we generate large-scale datasets of high-fidelity electrophysiology simulations across diverse patient-specific anatomies and train customised neural operators to predict full-field local activation time maps. The proposed approach outperforms established neural operators on both atrial and ventricular geometries. Beyond cardiac electrophysiology, we further show that the same representation enables operator learning in cardiac biomechanics, a distinct problem involving volumetric deformation, highlighting the generality of the proposed framework. Together, these results establish intrinsic coordinate representations as a principled and extensible pathway for neural operator learning on complex physical systems characterised by heterogeneous geometry.
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