整理并标准化了上千例脑损伤患者的多中心MRI数据，发现15个脑区体积有显著差异。
Quality assurance of the Federal Interagency Traumatic Brain Injury Research (FITBIR) database for multi-site MRI analysis
- 将26项研究的结构与扩散MRI数据统一为标准格式
- 4868人有高质量结构像，2666人有扩散像，分析132个脑区体积
- 通过统计模型发现15个脑区在脑损伤患者中明显不同，适合临床研究者参考
联邦跨机构创伤性脑损伤研究（FITBIR）数据库是创伤性脑损伤（TBI）研究的集中数据仓库，包含来自6,211名受试者（9,229次成像会话）的超过45,529张磁共振图像（MRI），涵盖26项研究，具有异构的组织格式、成像对比度、采集参数和人群特征。本文将所有可用的结构与扩散MRI数据及相关人口学信息统一整理至脑影像数据结构（Brain Imaging Data Structure）。使用UNesT分割方法分析全脑平均各向异性（mean fractional anisotropy）、平均弥散率（mean diffusivity）、总颅腔容积及132个感兴趣区的体积。经过质量控制与数据调和后，共保留4,868名受试者（7,035次会话）的结构像，以及2,666名受试者（3,763次会话）的扩散像。采用广义加性模型对位置、尺度与形状（GAMLSS）建模，分析这些指标随年龄的变化趋势，并发现脑损伤患者与对照组在15个脑区体积上存在显著差异（q < 0.05，似然比检验经多重检验校正）。
原文摘要 · Abstract (English)
The Federal Interagency Traumatic Brain Injury Research (FITBIR) database is a centralized data repository for traumatic brain injury (TBI) research. It includes over 45,529 magnetic resonance images (MRI) from 6,211 subjects (9,229 imaging sessions) across 26 studies with heterogeneous organization formats, contrasts, acquisition parameters, and demographics. In this work, we organized and harmonized all available structural and diffusion MRI from FITBIR along with relevant demographic information into the Brain Imaging Data Structure. We analyzed whole-brain mean fractional anisotropy, mean diffusivity, total intracranial volume, and the volumes of 132 regions of interest using UNesT segmentations. There were 4,868 subjects (7,035 sessions) with structural MRI and 2,666 subjects (3,763 sessions) with diffusion MRI following quality assurance and harmonization. We modeled profiles for these metrics across ages with generalized additive models for location, scale, and shape (GAMLSS) and found significant differences in subjects with TBI compared to controls in volumes of 15 regions of the brain (q < 0.05, likelihood ratio test with false discovery rate correction).
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