无需医学检测,用大数据模型一次性预测上千种疾病。
Medical Test-free Disease Detection Based on Big Data
- 基于患者与疾病关联图,自适应融合病患特征和疾病关系
- 在MIMIC-IV数据集上召回率提升6.33%,精确率提升7.63%
- 适合大规模筛查、医疗资源不足场景,结果可解释
准确的疾病检测对有效治疗和患者护理至关重要。然而,疾病检测常依赖大量医学检查,成本高昂,难以对每位患者进行数百乃至数千种疾病的全面检测。本文提出一种基于图的深度学习模型CLDD,将疾病检测建模为协作学习任务,通过自适应利用疾病间关联和患者间相似性,在极少依赖医学检测的前提下,为每位患者同时预测数百至数千种疾病。在包含61,191名患者和2,000种疾病的MIMIC-IV数据集上,CLDD在多个指标上均显著优于主流基线方法,召回率提升6.33%,精确率提升7.63%。案例研究表明,CLDD能成功识别被隐藏的疾病,并将其排在高置信度预测前列,展现出良好的可解释性与可靠性。该方法有望降低诊断成本,提升疾病筛查覆盖率,推动社会健康保障体系建设。
原文摘要 · Abstract (English)
Accurate disease detection is of paramount importance for effective medical treatment and patient care. However, the process of disease detection is often associated with extensive medical testing and considerable costs, making it impractical to perform all possible medical tests on a patient to diagnose or predict hundreds or thousands of diseases. In this work, we propose Collaborative Learning for Disease Detection (CLDD), a novel graph-based deep learning model that formulates disease detection as a collaborative learning task by exploiting associations among diseases and similarities among patients adaptively. CLDD integrates patient-disease interactions and demographic features from electronic health records to detect hundreds or thousands of diseases for every patient, with little to no reliance on the corresponding medical tests. Extensive experiments on a processed version of the MIMIC-IV dataset comprising 61,191 patients and 2,000 diseases demonstrate that CLDD consistently outperforms representative baselines across multiple metrics, achieving a 6.33\% improvement in recall and 7.63\% improvement in precision. Furthermore, case studies on individual patients illustrate that CLDD can successfully recover masked diseases within its top-ranked predictions, demonstrating both interpretability and reliability in disease prediction. By reducing diagnostic costs and improving accessibility, CLDD holds promise for large-scale disease screening and social health security.
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