arXiv:2512.09013cs.LGphysics.flu-dyn2025-12被引 1

用图神经网络1分钟内完成脑动脉瘤血流模拟,助力临床风险评估。

Graph Deep Learning for Intracranial Aneurysm Blood Flow Simulation and Risk Assessment

  • 构建图变换器+自回归预测模型,从血管几何直接生成血流场
  • 单周期仿真耗时<1分钟,准确率媲美传统高精度模拟
  • 无需专家干预,可直接接入医院影像流程,适合临床使用

脑动脉瘤仍是全球神经科致残与致死的主要原因,其破裂风险与局部血流动力学密切相关,尤其是壁面剪切应力和振荡剪切指数。传统计算流体动力学模拟虽精确但耗时极长且需专业技能;4D Flow MRI虽可提供在体测量,但空间分辨率不足,且成本高昂、难以普及。本文提出一种图神经网络代理模型,仅需不到一分钟即可从患者特异性血管几何重建全域血流、壁面剪切应力与振荡剪切指数。模型基于大规模高保真模拟数据训练,结合图变压器与自回归预测,可在未见患者几何与入流条件下实现泛化,无需网格特定校准。该框架不仅显著加速仿真,更构建了可解释的血流动力学预测基础,支持与现有医院相位图评估直接对比,并引入物理可信的高分辨率流场。本研究将高保真模拟从专家专属工具转变为可部署的数据驱动决策支持系统,整个流程在获得患者影像后几分钟内完成高分辨率血流预测,无需计算专家,推动脑动脉瘤分析迈向实时床旁应用。

原文摘要 · Abstract (English)

Intracranial aneurysms remain a major cause of neurological morbidity and mortality worldwide, where rupture risk is tightly coupled to local hemodynamics particularly wall shear stress and oscillatory shear index. Conventional computational fluid dynamics simulations provide accurate insights but are prohibitively slow and require specialized expertise. Clinical imaging alternatives such as 4D Flow MRI offer direct in-vivo measurements, yet their spatial resolution remains insufficient to capture the fine-scale shear patterns that drive endothelial remodeling and rupture risk while being extremely impractical and expensive. We present a graph neural network surrogate model that bridges this gap by reproducing full-field hemodynamics directly from vascular geometries in less than one minute per cardiac cycle. Trained on a comprehensive dataset of high-fidelity simulations of patient-specific aneurysms, our architecture combines graph transformers with autoregressive predictions to accurately simulate blood flow, wall shear stress, and oscillatory shear index. The model generalizes across unseen patient geometries and inflow conditions without mesh-specific calibration. Beyond accelerating simulation, our framework establishes the foundation for clinically interpretable hemodynamic prediction. By enabling near real-time inference integrated with existing imaging pipelines, it allows direct comparison with hospital phase-diagram assessments and extends them with physically grounded, high-resolution flow fields. This work transforms high-fidelity simulations from an expert-only research tool into a deployable, data-driven decision support system. Our full pipeline delivers high-resolution hemodynamic predictions within minutes of patient imaging, without requiring computational specialists, marking a step-change toward real-time, bedside aneurysm analysis.

图神经网络血流模拟脑动脉瘤临床决策

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