arXiv:2512.14094eess.IVeess.SP2025-12

用合成孔径技术提升声电成像的空间分辨率,实现厘米级器官的清晰电场成像。

Synthetic Aperture for High Spatial Resolution Acoustoelectric Imaging

  • 通过无聚焦超声信号的延迟叠加重建,动态合成声电调制区域。
  • 相干加权后图像信噪比超越传统聚焦超声,且在全深度保持高分辨率。
  • 适合快速生物电流成像,尤其对深层组织电活动检测有优势。

声电(AE)成像通过超声波在组织中调制电阻率,映射电场分布以获得电解剖对比。传统方法使用聚焦超声(FUS-AE),但其有效深度仅限于焦点大小,无法覆盖厘米级器官。本文提出合成孔径声电成像(SA-AE),通过像素级延迟叠加重构未聚焦的AE信号。盐水和离体龙虾神经实验表明,FUS-AE仅在焦点处表现良好,焦点外电场源空间分辨率差;而SA-AE在全深度改善了分辨率,但引入强背景噪声。进一步利用单阵元激发的非耦合信号,量化了发射孔径上的空间相干性,获得相干因子(CF)与脉冲长度相干因子(CFPL)。将图像以推导出的CF和CFPL加权后,显著提升了分辨率、对比度,并显著提高信噪比(SNR)超过FUS-AE。CFPL在降噪方面优于CF。该方法利用非聚焦波传输,为快速生物电流的高分辨率、抗噪成像提供了实用解决方案。

原文摘要 · Abstract (English)

Acoustoelectric (AE) imaging provides electro-anatomical contrast by mapping the distribution of electric fields in biological tissues, by delivering ultrasound waves which spatially modulate the medium resistivity via the AE effect. The conventional method in AE imaging is to transmit focused ultrasound (FUS) beams; however, the depth-of-field (DOF) of FUS-AE is limited to the size of the focal spot, which does not span across the centimeter-scale of organs. Instead of fixing the focal depth on transmission, we propose to dynamically synthesize the AE modulation regions via a Synthetic Aperture approach (SA-AE). SA-AE involves a straightforward pixel-based delay-and-sum reconstruction of AE images from unfocused AE signals. In saline and ex vivo lobster nerve experiments, FUS-AE was shown to perform well only at the focal depth, with poor spatial resolution for out-of-focus electric sources. Meanwhile, SA-AE generally improved spatial resolution throughout the DOF, but introduced strong background noise. The flexibility of uncoupled, single-element induced AE signals in SA-AE was further leveraged to quantify their spatial coherence across the transmit aperture, obtaining maps of the coherence factor (CF) and pulse-length coherence factor (CFPL). Weighting SA-AE images with their derived CF and CFPL maps resulted in further improvement in image resolution and contrast, and notably, boosted the image SNR beyond that of FUS-AE. CFPL exhibited stronger noise suppression over CF. Using unfocused wave transmissions, the proposed coherence-weighted SA-AE strategy offers a high resolution yet noise-robust solution towards the practical imaging of fast biological currents.

声电成像合成孔径空间分辨率生物电流

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