arXiv:2512.14461cs.LGeess.SP2025-12被引 1

AnySleep可任意输入脑电/眼动数据,实现高分辨率睡眠分期。

AnySleep: a channel-agnostic deep learning system for high-resolution sleep staging in multi-center cohorts

  • 基于深度学习,兼容任意电极配置与采样率
  • 在20万小时数据上训练,跨中心泛化能力强
  • 支持秒级睡眠分析,提升疾病诊断精度

睡眠对健康至关重要,但其研究依赖人工睡眠分期,耗时费力。传统多中心多导睡眠图(PSG)记录按30秒分段,非生理依据,且电极数量、布局和受试者特征各异,阻碍多中心研究与短时程生物标志物发现。本文提出AnySleep,一种深度神经网络模型,可从任意脑电(EEG)或眼动(EOG)数据中进行可调时间分辨率的睡眠分期。模型在来自28个中心的超过20,000例整夜记录(>200,000小时的EEG/EOG)上训练与验证,实现当前最优性能,并在30秒分段下超越或持平现有基线。性能随通道数增加而提升,即使缺少EOG或仅有单一导联(额叶、中央、枕叶EEG)仍保持良好表现。在小于30秒的时间尺度下,模型能捕捉短暂觉醒事件,显著提升对阻塞性睡眠呼吸暂停、1型发作性睡病、失眠等病理状态的预测能力。模型已公开,助力异构电极设置下的大规模研究与睡眠生物标志物发现。

原文摘要 · Abstract (English)

Sleep is essential for health, yet studying its dynamics requires manual sleep staging, a labor-intensive step in research and clinical care. Across centers, polysomnography (PSG) recordings are traditionally scored in 30-s epochs for pragmatic, not physiological, reasons and vary in electrode count, montage, and subject characteristics. These constraints challenge harmonized multi-center studies and the discovery of robust biomarkers on shorter timescales. We present AnySleep, a deep neural network that scores sleep from any electroencephalography (EEG) or electrooculography (EOG) data at adjustable temporal resolutions. We trained and validated the model on over 20,000 overnight recordings (> 200,000 hours of EEG and EOG) from 28 datasets across multiple clinics to promote robust generalization across sites. The model attains state-of-the-art performance and surpasses or equals established baselines at 30-s epochs. Performance improves with more channels, yet remains strong when EOG is absent or only EOG or single EEG derivations (frontal, central, or occipital) are available. On sub-30-s timescales, the model captures short wake intrusions consistent with arousals and improves prediction of pathophysiological conditions (obstructive sleep apnea, narcolepsy type 1, insomnia) over 30-s scoring. We make the model publicly available to facilitate large-scale studies with heterogeneous electrode setups and accelerate biomarker discovery in sleep.

睡眠分期深度学习多中心研究高分辨率

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