arXiv:2512.15761cs.LGphysics.flu-dyn2025-12被引 1

用机器学习把血泵流场特征和血栓风险关联起来,又快又看得懂。

Machine Learning Framework for Thrombosis Risk Prediction in Rotary Blood Pumps

  • 基于流体模拟数据,用可解释的机器学习找关键流场特征
  • 在两种工况下准确复现血栓风险分布,识别出高风险区域
  • 计算成本低,适合快速筛查血泵设计中的血栓隐患

旋转血泵中的血栓形成源于复杂的流动条件,现有计算模型难以将其转化为可靠且可解释的风险预测。本研究提出一种基于计算流体动力学(CFD)流场特征的可解释机器学习框架,用于空间血栓风险评估。采用逻辑回归(LR)模型结合结构化特征选择流程,提取出紧凑且具有物理意义的特征集,包括非线性特征组合。该框架利用两种代表性工况下经过验证的宏观尺度血栓模型生成的空间风险模式进行训练。模型成功复现了标注的风险分布,并识别出与血栓风险增加相关的特定流场特征。应用于离心泵时,尽管仅在单一轴向泵工况下训练,仍能预测出合理的血栓高风险区域。结果表明,可解释的机器学习能够将局部流场特征与血栓风险有效关联,兼具计算效率与机制透明性。低成本特性支持无需重复昂贵仿真即可实现快速血栓易发性筛查。该框架补充了基于物理的血栓建模方法,为将可解释机器学习整合进基于CFD的血栓分析与器械设计流程提供了方法基础。

原文摘要 · Abstract (English)

Thrombosis in rotary blood pumps arises from complex flow conditions that remain difficult to translate into reliable and interpretable risk predictions using existing computational models. This limitation reflects an incomplete understanding of how specific flow features contribute to thrombus initiation and growth. This study introduces an interpretable machine learning framework for spatial thrombosis assessment based directly on computational fluid dynamics-derived flow features. A logistic regression (LR) model combined with a structured feature-selection pipeline is used to derive a compact and physically interpretable feature set, including nonlinear feature combinations. The framework is trained using spatial risk patterns from a validated, macro-scale thrombosis model for two representative scenarios. The model reproduces the labeled risk distributions and identifies distinct sets of flow features associated with increased thrombosis risk. When applied to a centrifugal pump, despite training on a single axial pump operating point, the model predicts plausible thrombosis-prone regions. These results show that interpretable machine learning can link local flow features to thrombosis risk while remaining computationally efficient and mechanistically transparent. The low computational cost enables rapid thrombogenicity screening without repeated or costly simulations. The proposed framework complements physics-based thrombosis modeling and provides a methodological basis for integrating interpretable machine learning into CFD-driven thrombosis analysis and device design workflows.

血栓预测机器学习血泵设计CFD分析

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