统一模型自动分割脑肿瘤FLAIR高信号区,跨类型跨时间点表现稳定。
A unified FLAIR hyperintensity segmentation model for various CNS tumor types and acquisition time points
- 用注意力U-Net构建统一分割模型,融合多中心、多时相数据训练。
- 对胶质瘤、脑膜瘤等各类肿瘤平均Dice达84.6%,与专用模型相当。
- 可直接部署于临床工具Raidionics,支持多场景脑肿瘤分析。
T2加权液体抑制反转恢复(FLAIR)MRI在脑肿瘤诊断、治疗规划和监测中至关重要。不同肿瘤类型的FLAIR高信号体积可用于评估肿瘤范围或周围水肿,自动分割具有重要临床价值。本研究利用来自多个中心的约5000张不同肿瘤类型及采集时间点的FLAIR图像,基于注意力U-Net架构训练了一个统一的高信号区分割模型。性能对比了特定数据集模型,并在多种肿瘤类型、不同采集时间点及BraTS数据集上进行验证。统一模型在术前脑膜瘤上达到88.65%的平均Dice分数,术前转移瘤为80.08%,术前及术后胶质瘤分别为90.92%和84.60%,低级别胶质瘤术前和术后分别为84.47%和61.27%。结果表明,该模型在各数据集上的表现与专用模型相当,具备跨肿瘤类型和采集时间点的泛化能力,便于临床部署。模型已集成至Raidionics——一个开源的中枢神经系统肿瘤分析软件。
原文摘要 · Abstract (English)
T2-weighted fluid-attenuated inversion recovery (FLAIR) magnetic resonance imaging (MRI) scans are important for diagnosis, treatment planning and monitoring of brain tumors. Depending on the brain tumor type, the FLAIR hyperintensity volume is an important measure to asses the tumor volume or surrounding edema, and an automatic segmentation of this would be useful in the clinic. In this study, around 5000 FLAIR images of various tumors types and acquisition time points from different centers were used to train a unified FLAIR hyperintensity segmentation model using an Attention U-Net architecture. The performance was compared against dataset specific models, and was validated on different tumor types, acquisition time points and against BraTS. The unified model achieved an average Dice score of 88.65\% for pre-operative meningiomas, 80.08% for pre-operative metastasis, 90.92% for pre-operative and 84.60% for post-operative gliomas from BraTS, and 84.47% for pre-operative and 61.27\% for post-operative lower grade gliomas. In addition, the results showed that the unified model achieved comparable segmentation performance to the dataset specific models on their respective datasets, and enables generalization across tumor types and acquisition time points, which facilitates the deployment in a clinical setting. The model is integrated into Raidionics, an open-source software for CNS tumor analysis.
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