用深度学习分析脑电图,判断电刺激后的意识状态。
Deep Learning Classification of EEG Responses to Multi-Dimensional Transcranial Electrical Stimulation
- 用卷积神经网络分析多维经颅电刺激后的脑电反应
- 模型在未参与训练的受试者上达92%分类准确率
- 结果可复现,数据代码开源适合神经与AI研究
当前医疗实践中缺乏客观的意识水平评估手段。意识障碍常见于脑损伤和癫痫发作,影响感知与自主反应,导致依赖指令响应的神经生理方法(如功能磁共振或脑电图)存在局限。经颅电刺激(TES)可无创激活大脑,绕过感官输入,已有潜力作为脑状态可靠指标。但现有非侵入性方案多限于磁刺激,难以临床应用。本研究提出一种深度学习框架,用于分类由特定多维模式的TES诱发的脑电反应。在11名受试者中采集了EEG-TES数据,发现对后皮层区域(角回)施加经颅直流电刺激(tDCS)可引发高度一致的脑反应。最佳卷积神经网络模型在未参与训练的受试者数据上达到92%的分类F1分数,显著超过人类水平的60-70%准确率。该研究建立了可用于临床的意识状态测量框架,并完整公开数据集与代码库,供神经科学与人工智能研究社区自由使用,支持通过GitHub、Kaggle、Colab等平台复现结果。
原文摘要 · Abstract (English)
A major shortcoming of medical practice is the lack of an objective measure of conscious level. Impairment of consciousness is common, e.g. following brain injury and seizures, which can also interfere with sensory processing and volitional responses. This is also an important pitfall in neurophysiological methods that infer awareness via command following, e.g. using functional MRI or electroencephalography (EEG). Transcranial electrical stimulation (TES) can be employed to non-invasively stimulate the brain, bypassing sensory inputs, and has already showed promising results in providing reliable indicators of brain state. However, current non-invasive solutions have been limited to magnetic stimulation, which is not easily translatable to clinical settings. Our long-term vision is to develop an objective measure of brain state that can be used at the bedside, without requiring patients to understand commands or initiate motor responses. In this study, we demonstrated the feasibility of a framework using Deep Learning algorithms to classify EEG brain responses evoked by a defined multi-dimensional pattern of TES. We collected EEG-TES data from 11 participants and found that delivering transcranial direct current stimulation (tDCS) to posterior cortical areas targeting the angular gyrus elicited an exceptionally reliable brain response. For this paradigm, our best Convolutional Neural Network model reached a 92% classification F1-score on Holdout data from participants never seen during training, significantly surpassing human-level performance at 60-70% accuracy. These findings establish a framework for robust consciousness measurement for clinical use. In this spirit, we documented and open-sourced our datasets and codebase in full, to be used freely by the neuroscience and AI research communities, who may replicate our results with free tools like GitHub, Kaggle, and Colab.
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