融合病理上下文与专家经验,提升眼病识别准确率与可解释性
Pathology Context Recalibration Network for Ocular Disease Recognition
- 设计病理重校准模块,结合像素级上下文压缩与分布集中机制
- 引入专家先验引导适配器,突出关键视觉区域,提升模型判别力
- 在3个数据集上超越现有注意力模型,适合医学影像智能诊断研究者
病理上下文与专家经验在临床眼病诊断中至关重要。尽管深度神经网络(DNN)在眼病识别上表现良好,但常忽略利用临床病理上下文和专家经验先验来提升识别性能与决策可解释性。为此,本文提出一种新型病理重校准模块(PRM),通过精心设计的像素级上下文压缩算子与病理分布集中算子,挖掘病理上下文先验;进一步引入专家先验引导适配器(EPGA),充分挖掘专家经验先验,突出显著像素级表征区域。将PRM与EPGA集成至现代DNN中,构建用于自动眼病识别的PCRNet。此外,设计综合损失(IL),考虑样本级损失分布与训练标签频率的影响,以提升识别性能。在三个眼病数据集上的大量实验表明,含IL的PCRNet优于当前最先进的基于注意力的网络与先进损失方法。可视化分析揭示了PRM与EPGA影响DNN决策过程的内在机制。
原文摘要 · Abstract (English)
Pathology context and expert experience play significant roles in clinical ocular disease diagnosis. Although deep neural networks (DNNs) have good ocular disease recognition results, they often ignore exploring the clinical pathology context and expert experience priors to improve ocular disease recognition performance and decision-making interpretability. To this end, we first develop a novel Pathology Recalibration Module (PRM) to leverage the potential of pathology context prior via the combination of the well-designed pixel-wise context compression operator and pathology distribution concentration operator; then this paper applies a novel expert prior Guidance Adapter (EPGA) to further highlight significant pixel-wise representation regions by fully mining the expert experience prior. By incorporating PRM and EPGA into the modern DNN, the PCRNet is constructed for automated ocular disease recognition. Additionally, we introduce an Integrated Loss (IL) to boost the ocular disease recognition performance of PCRNet by considering the effects of sample-wise loss distributions and training label frequencies. The extensive experiments on three ocular disease datasets demonstrate the superiority of PCRNet with IL over state-of-the-art attention-based networks and advanced loss methods. Further visualization analysis explains the inherent behavior of PRM and EPGA that affects the decision-making process of DNNs.
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