用物理仿真与确定性投影,一次完成牙科CT金属伪影消除
Physically-Grounded Manifold Projection Model for Generalizable Metal Artifact Reduction in Dental CBCT
- 基于患者数字孪生和蒙特卡洛建模生成真实感训练数据
- 单次前向传播完成去伪影,速度比扩散模型快100倍以上
- 融合医学大模型先验,避免结构幻觉,适合临床部署
牙科锥形束CT中的金属伪影严重遮挡解剖结构,影响诊断。现有深度学习方法存在局限:监督方法因“回归均值”导致光谱模糊,无监督方法则易引发结构幻觉。去噪扩散模型虽具真实性,但依赖缓慢的随机迭代采样,不适用于临床。为此,我们提出物理基础流形投影框架(PGMP)。首先,解剖自适应物理仿真(AAPS)管道通过蒙特卡洛光谱建模与患者特异性数字孪生生成高保真训练对,弥合合成与真实间的差距。其次,DMP-Former采用直接x预测范式,将恢复重构为确定性流形投影,在单次前向传播中恢复干净解剖结构,消除随机采样。最后,语义结构对齐(SSA)模块利用医学基础模型(MedDINOv3)的先验知识锚定解法,确保临床合理性。在合成及多中心临床数据集上的实验表明,PGMP在未见解剖结构上超越现有最佳方法,实现了效率与诊断可靠性新基准。代码与数据:https://github.com/ricoleehduu/PGMP。
原文摘要 · Abstract (English)
Metal artifacts in Dental CBCT severely obscure anatomical structures, hindering diagnosis. Current deep learning for Metal Artifact Reduction (MAR) faces limitations: supervised methods suffer from spectral blurring due to "regression-to-the-mean", while unsupervised ones risk structural hallucinations. Denoising Diffusion Models (DDPMs) offer realism but rely on slow, stochastic iterative sampling, unsuitable for clinical use. To resolve this, we propose the Physically-Grounded Manifold Projection (PGMP) framework. First, our Anatomically-Adaptive Physics Simulation (AAPS) pipeline synthesizes high-fidelity training pairs via Monte Carlo spectral modeling and patient-specific digital twins, bridging the synthetic-to-real gap. Second, our DMP-Former adapts the Direct x-Prediction paradigm, reformulating restoration as a deterministic manifold projection to recover clean anatomy in a single forward pass, eliminating stochastic sampling. Finally, a Semantic-Structural Alignment (SSA) module anchors the solution using priors from medical foundation models (MedDINOv3), ensuring clinical plausibility. Experiments on synthetic and multi-center clinical datasets show PGMP outperforms state-of-the-art methods on unseen anatomy, setting new benchmarks in efficiency and diagnostic reliability. Code and data: https://github.com/ricoleehduu/PGMP.
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