提出可解释的智能体框架,让AI在中风影像中不确定时主动放弃判断。
An Explainable Agentic AI Framework for Uncertainty-Aware and Abstention-Enabled Acute Ischemic Stroke Imaging Decisions
- 分模块智能体流程:感知、估不确定性、决策是否预测
- 在模糊区域自动放弃判断,提升临床安全
- 支持预测与拒判的可视化解释,适合急诊影像场景
人工智能在急性缺血性中风影像中展现强大潜力,尤其在CT和MRI上的病灶检测与分割。然而,现有方法多为黑箱预测,缺乏不确定性意识和明确的拒判机制,这在高风险急诊放射科环境中引发严重安全与信任问题。本文提出一种可解释的智能体AI框架,实现中风影像决策中的不确定性感知与选择性拒判。该框架采用模块化智能体流程:感知代理执行病灶感知图像分析,不确定性估计代理计算切片级预测可靠性,决策代理根据预设阈值决定是否输出预测或拒判。定性及案例分析表明,不确定性驱动的拒判在诊断模糊区域和低信息切片中自然出现。框架还集成视觉解释机制,支持预测与拒判的可解释性,弥补现有系统短板。本研究不设新性能基准,而是将智能体控制、不确定性感知与选择性拒判确立为构建安全可信医疗影像AI的核心设计原则。
原文摘要 · Abstract (English)
Artificial intelligence models have shown strong potential in acute ischemic stroke imaging, particularly for lesion detection and segmentation using computed tomography and magnetic resonance imaging. However, most existing approaches operate as black box predictors, producing deterministic outputs without explicit uncertainty awareness or structured mechanisms to abstain under ambiguous conditions. This limitation raises serious safety and trust concerns in high risk emergency radiology settings. In this paper, we propose an explainable agentic AI framework for uncertainty aware and abstention enabled decision support in acute ischemic stroke imaging. The framework follows a modular agentic pipeline in which a perception agent performs lesion aware image analysis, an uncertainty estimation agent computes slice level predictive reliability, and a decision agent determines whether to issue a prediction or abstain based on predefined uncertainty thresholds. Unlike prior stroke imaging systems that primarily focus on improving segmentation or classification accuracy, the proposed framework explicitly prioritizes clinical safety, transparency, and clinician aligned decision behavior. Qualitative and case based analyses across representative stroke imaging scenarios demonstrate that uncertainty driven abstention naturally emerges in diagnostically ambiguous regions and low information slices. The framework further integrates visual explanation mechanisms to support both predictive and abstention decisions, addressing a key limitation of existing uncertainty aware medical imaging systems. Rather than introducing a new performance benchmark, this work presents agentic control, uncertainty awareness, and selective abstention as essential design principles for developing safe and trustworthy medical imaging AI systems.
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