arXiv:2601.01229eess.SPcs.LG2026-01被引 6

神经SSM模型同步捕捉脑影像中的快慢动态,提升对认知过程的敏感性。

NeuroSSM: Multiscale Differential State-Space Modeling for Context-Aware fMRI Analysis

  • 多尺度状态空间结构并行建模快慢动态,保留原始血氧信号特征
  • 新增差分分支增强对瞬时变化的敏感度,显著提升对短期事件的检测能力
  • 适用于临床与非临床脑功能研究,尤其适合长期序列分析

准确的fMRI分析需兼顾跨多时间尺度的时序结构,因为BOLD信号编码了从快速瞬变动态到较慢整体波动的认知过程。现有深度学习方法在长时序建模上存在挑战。虽然变换器通过注意力机制显式建模长程依赖,但其二次计算开销限制了在长序列中的应用;而选择性状态空间模型(SSMs)通过隐状态演化隐式建模长程依赖,具备高效传播优势。然而,当前基于SSM的fMRI方法通常作用于衍生的功能连接表示,并采用单尺度处理,难以同时表征快速瞬变与慢速全局趋势。本文提出NeuroSSM,一种面向原始BOLD信号端到端分析的选择性状态空间架构。其核心创新包括:多尺度状态空间主干网络,可并发捕捉快慢动态;并行差分分支,提升对瞬时状态变化的敏感性。在临床与非临床数据集上的实验表明,NeuroSSM在性能与效率上均达到当前先进水平。

原文摘要 · Abstract (English)

Accurate fMRI analysis requires sensitivity to temporal structure across multiple scales, as BOLD signals encode cognitive processes that emerge from fast transient dynamics to slower, large-scale fluctuations. Existing deep learning (DL) approaches to temporal modeling face challenges in jointly capturing these dynamics over long fMRI time series. Among current DL models, transformers address long-range dependencies by explicitly modeling pairwise interactions through attention, but the associated quadratic computational cost limits effective integration of temporal dependencies across long fMRI sequences. Selective state-space models (SSMs) instead model long-range temporal dependencies implicitly through latent state evolution in a dynamical system, enabling efficient propagation of dependencies over time. However, recent SSM-based approaches for fMRI commonly operate on derived functional connectivity representations and employ single-scale temporal processing. These design choices constrain the ability to jointly represent fast transient dynamics and slower global trends within a single model. We propose NeuroSSM, a selective state-space architecture designed for end-to-end analysis of raw BOLD signals in fMRI time series. NeuroSSM addresses the above limitations through two complementary design components: a multiscale state-space backbone that captures fast and slow dynamics concurrently, and a parallel differencing branch that increases sensitivity to transient state changes. Experiments on clinical and non-clinical datasets demonstrate that NeuroSSM achieves competitive performance and efficiency against state-of-the-art fMRI analysis methods.

fMRI分析状态空间模型多尺度建模脑功能成像

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