用大模型模拟人群对政策的反应，提升预测准确性与可解释性。

Predicting how populations respond to policy interventions is a fundamental challenge in computational social science and public policy. Traditional approaches rely on aggregate statistical models that capture historical correlations but lack mechanistic interpretability and struggle with novel policy scenarios. We present a general framework for constructing Social Digital Twins - virtual population replicas where Large Language Models (LLMs) serve as cognitive engines for individual agents. Each agent, characterized by demographic and psychographic attributes, receives policy signals and outputs multi-dimensional behavioral probability vectors. A calibration layer maps aggregated agent responses to observable population-level metrics, enabling validation against real-world data and deployment for counterfactual policy analysis. We instantiate this framework in the domain of pandemic response, using COVID-19 as a case study with rich observational data. On a held-out test period, our calibrated digital twin achieves a 20.7% improvement in macro-averaged prediction error over gradient boosting baselines across six behavioral categories. Counterfactual experiments demonstrate monotonic and bounded responses to policy variations, establishing behavioral plausibility. The framework is domain-agnostic: the same architecture applies to transportation policy, economic interventions, environmental regulations, or any setting where policy affects population behavior. We discuss implications for policy simulation, limitations of the approach, and directions for extending LLM-based digital twins beyond pandemic response.