arXiv:2601.07969eess.AScs.AI2026-01被引 1

建立基于咳嗽音频与临床数据的结核病筛查基准模型,推动可比性研究。

Tuberculosis Screening from Cough Audio: Baseline Models, Clinical Variables, and Uncertainty Quantification

  • 融合咳嗽音频与临床数据,构建端到端可复现的多模态预测流程。
  • 在多国数据集上验证,音频+临床联合模型表现优于纯音频模型。
  • 提供完整实验协议和不确定性量化,助力公平对比与后续研究。

本文提出一种标准化框架,利用机器学习实现从咳嗽音频和常规临床数据中自动检测结核病(TB)。尽管基于音频的结核筛查日益受到关注,但现有研究在数据集、队列定义、特征表示、模型类型、验证方案和报告指标等方面差异巨大,导致性能提升难以直接比较,且无法判断改进是来自建模进步还是数据或评估方式差异。为此,我们基于近期整合自多个国家的公开数据集,建立了强而透明的结核病预测基线。该流程涵盖特征提取、多模态融合、独立于咳嗽者评估及不确定性量化,报告一组一致的临床相关指标,支持公平比较。我们进一步量化了仅音频模型与融合模型(音频+临床元数据)的表现,并发布完整实验协议,以促进基准测试。该基线旨在成为领域内的共同参考点,减少方法学差异对研究进展的阻碍。

原文摘要 · Abstract (English)

In this paper, we propose a standardized framework for automatic tuberculosis (TB) detection from cough audio and routinely collected clinical data using machine learning. While TB screening from audio has attracted growing interest, progress is difficult to measure because existing studies vary substantially in datasets, cohort definitions, feature representations, model families, validation protocols, and reported metrics. Consequently, reported gains are often not directly comparable, and it remains unclear whether improvements stem from modeling advances or from differences in data and evaluation. We address this gap by establishing a strong, well-documented baseline for TB prediction using cough recordings and accompanying clinical metadata from a recently compiled dataset from several countries. Our pipeline is reproducible end-to-end, covering feature extraction, multimodal fusion, cougher-independent evaluation, and uncertainty quantification, and it reports a consistent suite of clinically relevant metrics to enable fair comparison. We further quantify performance for cough audio-only and fused (audio + clinical metadata) models, and release the full experimental protocol to facilitate benchmarking. This baseline is intended to serve as a common reference point and to reduce methodological variance that currently holds back progress in the field.

结核病筛查多模态学习音频分析不确定性量化

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