arXiv:2601.11923cs.CL2026-01

分析25年中医辅助放疗研究演化,揭示其从扩张到成熟的周期性发展。

Mapping the maturation of TCM as an adjuvant to radiotherapy

  • 基于6.97万篇文献,发现研究呈现‘定义-构思-验证’循环演进模式。
  • 识别出癌症类型、支持治疗等五大核心主题,体现患者中心与系统思维。
  • 研究趋于成熟,正面临新方向突破,但存在普遍性正向报告偏差。

将补充医学融入肿瘤学标志着范式转变,近年来中医作为放疗辅助疗法的采用日益增加。在综合肿瘤学正式确立约二十五年后,对中医辅助放疗证据轨迹进行整合恰逢其时。本研究分析了2000至2025年间69,745篇文献,揭示出版数量、国际合作与资金投入呈现出协调的周期性扩张与收缩,映射出‘定义-构想-测试’的演进模式。通过设计的主题建模工作流,识别出五大主导主题轴:癌症类型、支持性护理、临床终点、作用机制和方法学,反映出对患者福祉、科学严谨性和机制探索的关注。中医的跨主题整合具有以患者为中心和系统导向特征。结合演进周期,主题结构表明该领域正经历专业化进程,可能出现研究格局的解构或现有议程饱和。分析显示,该领域已成熟其当前研究议程,正处在新阶段的临界点。此外,不同文献类型、主题领域及演进周期中均表现出一致的正向结果报告倾向,表明一种不依赖结构性驱动因素的系统性正向报告偏倚。

原文摘要 · Abstract (English)

The integration of complementary medicine into oncology represents a paradigm shift that has seen to increasing adoption of Traditional Chinese Medicine (TCM) as an adjuvant to radiotherapy. About twenty-five years since the formal institutionalization of integrated oncology, it is opportune to synthesize the trajectory of evidence for TCM as an adjuvant to radiotherapy. Here we conduct a large-scale analysis of 69,745 publications (2000 - 2025), emerging a cyclical evolution defined by coordinated expansion and contraction in publication output, international collaboration, and funding commitments that mirrors a define-ideate-test pattern. Using a theme modeling workflow designed to determine a stable thematic structure of the field, we identify five dominant thematic axes - cancer types, supportive care, clinical endpoints, mechanisms, and methodology - that signal a focus on patient well-being, scientific rigor and mechanistic exploration. Cross-theme integration of TCM is patient-centered and systems-oriented. Together with the emergent cycles of evolution, the thematic structure demonstrates progressive specialization and potential defragmentation of the field or saturation of existing research agenda. The analysis points to a field that has matured its current research agenda and is likely at the cusp of something new. Additionally, the field exhibits positive reporting of findings that is homogeneous across publication types, thematic areas, and the cycles of evolution suggesting a system-wide positive reporting bias agnostic to structural drivers.

中医放疗综述研究演化

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