用稀疏采样重建血流图像,提升速度与精度。
ASBA: A-line State Space Model and B-line Attention for Sparse Optical Doppler Tomography Reconstruction
- 分区域建模A线流动特征,结合相位注意力捕捉长程血流信号。
- 在真实动物数据上,重建质量显著优于现有方法。
- 适合需要快速高保真血流成像的医学研究与临床应用。
光学多普勒断层成像(ODT)是一种新兴的血流分析技术。二维ODT图像(B-scan)通过沿横向轴(B-line)逐次采集深度分辨的1维原始A-scans(A-line),再进行多普勒相位减法分析生成。为保证高质量的B-scan图像,当前方法依赖密集采样,导致扫描时间长、存储需求高,难以捕捉快速血流动态。近期研究尝试对原始A-scans进行稀疏采样以缓解此问题,但受限于保守的采样率及对流动与背景信号的均匀建模。本文提出一种新型血流感知网络ASBA(A-line ROI状态空间模型与B-line相位注意力),从高度稀疏的原始A-scans中重建ODT图像。具体地,设计A-line ROI状态空间模型以提取沿A-line稀疏分布的流动特征,引入B-line相位注意力机制,基于相位差捕捉各B-line上的长程流动信号。此外,提出一种血流感知加权损失函数,引导网络优先准确重建流动信号。在真实动物数据上的大量实验表明,所提方法明显优于现有最先进重建方法。
原文摘要 · Abstract (English)
Optical Doppler Tomography (ODT) is an emerging blood flow analysis technique. A 2D ODT image (B-scan) is generated by sequentially acquiring 1D depth-resolved raw A-scans (A-line) along the lateral axis (B-line), followed by Doppler phase-subtraction analysis. To ensure high-fidelity B-scan images, current practices rely on dense sampling, which prolongs scanning time, increases storage demands, and limits the capture of rapid blood flow dynamics. Recent studies have explored sparse sampling of raw A-scans to alleviate these limitations, but their effectiveness is hindered by the conservative sampling rates and the uniform modeling of flow and background signals. In this study, we introduce a novel blood flow-aware network, named ASBA (A-line ROI State space model and B-line phase Attention), to reconstruct ODT images from highly sparsely sampled raw A-scans. Specifically, we propose an A-line ROI state space model to extract sparsely distributed flow features along the A-line, and a B-line phase attention to capture long-range flow signals along each B-line based on phase difference. Moreover, we introduce a flow-aware weighted loss function that encourages the network to prioritize the accurate reconstruction of flow signals. Extensive experiments on real animal data demonstrate that the proposed approach clearly outperforms existing state-of-the-art reconstruction methods.
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