arXiv:2601.15042cs.CVcs.AI2026-01

联邦学习让多医院协作定位脑肿瘤,不传数据也能提升精度。

Federated Transformer-GNN for Privacy-Preserving Brain Tumor Localization with Modality-Level Explainability

  • 用混合Transformer-GNN模型,在不共享数据下联合训练
  • 联邦学习使模型持续优化,最终达到中心化训练效果
  • 通过注意力机制解释各核磁模态贡献,符合临床实际

脑肿瘤分析依赖大规模多样化数据,但受隐私法规限制,数据常分散于不同医疗机构。本文提出一种面向脑肿瘤定位的联邦学习框架,可在不共享患者数据的前提下实现多机构协作。方法基于先前无编码器的超体素GNN改进的混合Transformer-图神经网络架构,并部署于CERN设计的医疗专用联邦学习平台CAFEIN®。通过Transformer注意力机制进行可解释性分析,揭示影响模型预测的关键核磁模态。在BraTS数据集上的实验表明:单机构独立训练因早停而无法充分利用数据,而联邦学习通过融合分布式数据持续提升性能,最终匹配集中式训练表现。统计验证(配对t检验+邦弗朗尼校正)显示,深层网络显著增强对T2和FLAIR模态的关注(p<0.001,Cohen's d=1.50),与临床实践一致。

原文摘要 · Abstract (English)

Deep learning models for brain tumor analysis require large and diverse datasets that are often siloed across healthcare institutions due to privacy regulations. We present a federated learning framework for brain tumor localization that enables multi-institutional collaboration without sharing sensitive patient data. Our method extends a hybrid Transformer-Graph Neural Network architecture derived from prior decoder-free supervoxel GNNs and is deployed within CAFEIN\textsuperscript{\textregistered}, CERN's federated learning platform designed for healthcare environments. We provide an explainability analysis through Transformer attention mechanisms that reveals which MRI modalities drive the model predictions. Experiments on the BraTS dataset demonstrate a key finding: while isolated training on individual client data triggers early stopping well before reaching full training capacity, federated learning enables continued model improvement by leveraging distributed data, ultimately matching centralized performance. This result provides strong justification for federated learning when dealing with complex tasks and high-dimensional input data, as aggregating knowledge from multiple institutions significantly benefits the learning process. Our explainability analysis, validated through rigorous statistical testing on the full test set (paired t-tests with Bonferroni correction), reveals that deeper network layers significantly increase attention to T2 and FLAIR modalities ($p<0.001$, Cohen's $d$=1.50), aligning with clinical practice.

联邦学习脑肿瘤可解释性医学AI

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