让AI看懂寄生虫形态特征,提升诊断可解释性
MorphXAI: An Explainable Framework for Morphological Analysis of Parasites in Blood Smear Images
- 将形态特征监督融入检测流程,同步识别位置与形态
- 在三种寄生虫数据集上检测性能优于基线模型
- 输出结构化生物学解释,适合临床医生验证使用
寄生虫感染仍是全球重大健康挑战,尤其在资源匮乏地区,诊断仍依赖人工显微镜检查和专家经验。尽管深度学习在寄生虫检测中表现优异,但其临床应用受限于可解释性不足。现有解释方法多为热力图或注意力图,仅标注关注区域,无法捕捉临床诊断依赖的形态特征。本文提出MorphXAI,一个统一寄生虫检测与细粒度形态分析的可解释框架。该框架将形态监督直接嵌入预测流程,使模型在定位寄生虫的同时,可识别形状、曲率、可见点数、鞭毛存在及发育阶段等临床相关属性。为此,我们构建了一个由临床医生标注的数据集,涵盖利什曼原虫、布氏锥虫和克氏锥虫三种寄生虫,包含详细的形态标签,建立了可解释寄生虫分析的新基准。实验表明,MorphXAI不仅在检测性能上优于基线,还能提供结构化、生物意义明确的解释。
原文摘要 · Abstract (English)
Parasitic infections remain a pressing global health challenge, particularly in low-resource settings where diagnosis still depends on labor-intensive manual inspection of blood smears and the availability of expert domain knowledge. While deep learning models have shown strong performance in automating parasite detection, their clinical usefulness is constrained by limited interpretability. Existing explainability methods are largely restricted to visual heatmaps or attention maps, which highlight regions of interest but fail to capture the morphological traits that clinicians rely on for diagnosis. In this work, we present MorphXAI, an explainable framework that unifies parasite detection with fine-grained morphological analysis. MorphXAI integrates morphological supervision directly into the prediction pipeline, enabling the model to localize parasites while simultaneously characterizing clinically relevant attributes such as shape, curvature, visible dot count, flagellum presence, and developmental stage. To support this task, we curate a clinician-annotated dataset of three parasite species (Leishmania, Trypanosoma brucei, and Trypanosoma cruzi) with detailed morphological labels, establishing a new benchmark for interpretable parasite analysis. Experimental results show that MorphXAI not only improves detection performance over the baseline but also provides structured, biologically meaningful explanations.
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