arXiv:2601.18118cs.CVcs.AI2026-01

提出因果表征学习框架,提升肺癌诊疗可解释性与分类精度。

LungCRCT: Causal Representation based Lung CT Processing for Lung Cancer Treatment

  • 基于图自编码器与相关性解耦,挖掘肺癌进展的潜在因果因子。
  • 在恶性肿瘤分类任务中实现93.91% AUC,模型轻量化且鲁棒性强。
  • 适合关注肺癌诊疗可解释性与因果推断的研究者或临床决策支持系统开发者。

由于肺癌早期症状隐匿,已成为全球癌症患者死亡的主要原因之一。此外,肺癌主要症状常与慢性阻塞性肺病(COPD)等呼吸系统疾病混淆,导致患者难以在早期发现病情进展。因此,通过持续主动的呼吸系统监测实现早期检测,对提高肺癌生存率至关重要。目前最有效的方法之一是低剂量计算机断层扫描(LDCT)胸部影像,借助EfficientNet、ResNet等计算机视觉模型的快速发展,其在肺癌检测和肿瘤分类任务中已取得显著成效。然而,尽管基于迁移学习的深度卷积网络(CNN)或基于视觉变换器(ViT)的模型表现优异,但其固有的相关性依赖与高复杂度导致可解释性差,限制了其在肺癌治疗分析及因果干预模拟中的扩展。为此,本文提出LungCRCT:一种基于潜在因果表征学习的肺癌分析框架,旨在提取肺癌进展物理机制中的因果因素。该框架结合先进的图自编码器式因果发现算法、距离相关性解耦与基于熵的图像重建优化,不仅支持肺癌治疗的因果干预分析,还在恶性肿瘤分类任务中实现了93.91%的AUC,同时构建出轻量且鲁棒的下游模型。

原文摘要 · Abstract (English)

Due to silence in early stages, lung cancer has been one of the most leading causes of mortality in cancer patients world-wide. Moreover, major symptoms of lung cancer are hard to differentiate with other respiratory disease symptoms such as COPD, further leading patients to overlook cancer progression in early stages. Thus, to enhance survival rates in lung cancer, early detection from consistent proactive respiratory system monitoring becomes crucial. One of the most prevalent and effective methods for lung cancer monitoring would be low-dose computed tomography(LDCT) chest scans, which led to remarkable enhancements in lung cancer detection or tumor classification tasks under rapid advancements and applications of computer vision based AI models such as EfficientNet or ResNet in image processing. However, though advanced CNN models under transfer learning or ViT based models led to high performing lung cancer detections, due to its intrinsic limitations in terms of correlation dependence and low interpretability due to complexity, expansions of deep learning models to lung cancer treatment analysis or causal intervention analysis simulations are still limited. Therefore, this research introduced LungCRCT: a latent causal representation learning based lung cancer analysis framework that retrieves causal representations of factors within the physical causal mechanism of lung cancer progression. With the use of advanced graph autoencoder based causal discovery algorithms with distance Correlation disentanglement and entropy-based image reconstruction refinement, LungCRCT not only enables causal intervention analysis for lung cancer treatments, but also leads to robust, yet extremely light downstream models in malignant tumor classification tasks with an AUC score of 93.91%.

肺癌诊断因果表征图像分类可解释AI

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