用少量带装置的CT数据,显著提升膀胱分割精度。
Bridging the Applicator Gap with Data-Doping:Dual-Domain Learning for Precise Bladder Segmentation in CT-Guided Brachytherapy
- 用无装置和有装置数据混合训练,缓解分布偏移问题。
- 仅加入10%~30%有装置数据,分割效果接近纯有装置训练。
- 适合医学影像分割中数据稀缺场景,尤其适用于放疗规划。
深度学习模型在医学图像分割中常受协变量偏移影响导致性能下降。本文研究在目标域数据有限时,源域数据是否仍能有效辅助学习,聚焦于妇科腔内放疗中CT引导下的膀胱分割任务。尽管无施源器(NA)CT数据广泛可用,但含施源器(WA)的扫描稀少且存在显著解剖变形与成像伪影,自动化分割难度大。我们提出双域学习策略,融合NA与WA数据以增强鲁棒性与泛化能力。基于精心构建的数据集,实验表明仅用NA数据无法捕捉WA图像的解剖特征与伪影特性。然而,在以NA为主的数据集中引入10%~30%的WA数据,即可实现与纯WA训练模型相当的性能。跨轴向、冠状面、矢状面及多种深度网络架构的系统实验显示,该方法达到最高0.94的Dice相似系数和0.92的交并比,证明了有效的域适应与临床可靠性。研究强调,整合解剖相关但分布不同的数据集,可克服数据稀缺问题,提升放疗规划中的深度学习分割效果。
原文摘要 · Abstract (English)
Performance degradation due to covariate shift remains a major challenge for deep learning models in medical image segmentation. An open question is whether samples from a shifted distribution can effectively support learning when combined with limited target domain data. We investigate this problem in the context of bladder segmentation in CT guided gynecological brachytherapy, a critical task for accurate dose optimization and organ at risk sparing. While CT scans without brachytherapy applicators (no applicator: NA) are widely available, scans with applicators inserted (with applicator: WA) are scarce and exhibit substantial anatomical deformation and imaging artifacts, making automated segmentation particularly difficult. We propose a dual domain learning strategy that integrates NA and WA CT data to improve robustness and generalizability under covariate shift. Using a curated assorted dataset, we show that NA data alone fail to capture the anatomical and artifact related characteristics of WA images. However, introducing a modest proportion of WA data into a predominantly NA training set leads to significant performance improvements. Through systematic experiments across axial, coronal, and sagittal planes using multiple deep learning architectures, we demonstrate that doping only 10 to 30 percent WA data achieves segmentation performance comparable to models trained exclusively on WA data. The proposed approach attains Dice similarity coefficients of up to 0.94 and Intersection over Union scores of up to 0.92, indicating effective domain adaptation and improved clinical reliability. This study highlights the value of integrating anatomically similar but distribution shifted datasets to overcome data scarcity and enhance deep learning based segmentation for brachytherapy treatment planning.
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