用部分标注数据训练模型,精准分割脑部白质病变和中风病灶。
Comparative evaluation of training strategies using partially labelled datasets for segmentation of white matter hyperintensities and stroke lesions in FLAIR MRI
- 采用伪标签等六种策略,利用部分标注数据训练联合分割模型。
- 伪标签法效果最佳,对白质病变分割准确率高,能检测多数中风病灶。
- 适合做脑血管病影像分析的科研与临床研究者参考。
白质高信号(WMH)和缺血性中风病灶(ISL)是脑小血管病(SVD)的重要影像生物标志物,可在磁共振成像(MRI)上观察到。开发鲁棒的深度学习模型自动分割并区分这些病理仍具挑战性,因二者常共存于同一患者,且在液体抑制反转恢复(FLAIR)序列中表现为视觉混淆的高信号,难以准确界定。为应对完全标注队列稀缺问题,我们系统评估了六种使用部分标注数据训练联合WMH和ISL分割模型的策略。整合私有和公开数据集,构建包含2,052例MRI体积的大规模队列,其中1,341例和1,152例分别具备WMH和ISL的金标准标注。分析表明,多种策略均能有效利用部分标注数据提升模型性能,伪标签法表现最优。该模型展现出一致的WMH分割策略,并成功检测出大多数FLAIR阳性中风病灶。研究证明,利用部分标注数据开发可靠自动化分割工具具有可行性,可支持持续的SVD监测及大规模临床研究中的高通量生物标志物提取。
原文摘要 · Abstract (English)
White matter hyperintensities (WMH) and ischaemic stroke lesions (ISL) are key imaging biomarkers of cerebral small vessel disease (SVD) detectable on magnetic resonance imaging (MRI). The development of robust deep learning models to automatically segment and differentiate these pathologies remains challenging. Specifically, WMH and ISL frequently co-occur within the same subject and present as visually confounding hyperintensities on fluid-attenuated inversion recovery (FLAIR) sequences, complicating their accurate delineation. To address the scarcity of fully annotated cohorts, we systematically evaluated six accessible strategies for training a joint WMH and ISL segmentation model using partially labelled data. We aggregated privately held and publicly available datasets to curate a large-scale cohort of 2,052 MRI volumes, of which 1341 and 1152 volumes contained ground truth annotations for WMH and ISL, respectively. Our analysis indicates that multiple strategies effectively leverage partially labelled data to enhance overall model performance, with pseudolabelling emerging as the most effective approach. This model exhibited a consistent WMH segmentation policy and successfully detected the majority of FLAIR-positive ISL. These findings demonstrate the viability of using partially labelled data to develop reliable automated segmentation tools, which can support ongoing SVD monitoring and high-throughput biomarker extraction for large-scale clinical research.
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