为临床步态分析提供可信赖的不确定性估计,让系统自己判断结果靠不靠谱。
Calibrated Uncertainty for Trustworthy Clinical Gait Analysis Using Probabilistic Multiview Markerless Motion Capture
- 用概率建模方法估算关节角度后验分布,输出带置信区间的动作数据。
- 在68人数据上验证,步长和步态参数误差中位数分别为16毫米和12毫米。
- 预测的不确定性与实际误差强相关,能自动识别不可靠结果。
基于视频的人体运动分析在临床评估与研究中具有潜力,但其临床应用需确保多视角无标记运动捕捉(MMMC)不仅准确,还能提供可靠的置信区间以反映个体精度。本研究基于先前使用变分推断估计关节角后验分布的工作,评估了一种概率式MMMC方法的校准性与可靠性。我们在两家机构对68名受试者的数据进行了分析,通过测力步道与标准标记式运动捕捉进行验证。采用期望校准误差(ECE)衡量置信区间的校准程度。结果显示,该模型具备良好校准性,步长与步幅长度的ECE普遍小于0.1,且经偏差修正的步态运动学亦表现良好。步长与步幅的中位误差分别为约16毫米和12毫米,下肢各关节的偏差修正后运动学误差中位数介于1.5至3.8度之间。与校准的ECE一致,模型预测的不确定性与观测误差高度相关。结果表明,该概率模型能够量化认知不确定性,无需同步真实参考设备即可识别不可靠输出。
原文摘要 · Abstract (English)
Video-based human movement analysis holds potential for movement assessment in clinical practice and research. However, the clinical implementation and trust of multi-view markerless motion capture (MMMC) require that, in addition to being accurate, these systems produce reliable confidence intervals to indicate how accurate they are for any individual. Building on our prior work utilizing variational inference to estimate joint angle posterior distributions, this study evaluates the calibration and reliability of a probabilistic MMMC method. We analyzed data from 68 participants across two institutions, validating the model against an instrumented walkway and standard marker-based motion capture. We measured the calibration of the confidence intervals using the Expected Calibration Error (ECE). The model demonstrated reliable calibration, yielding ECE values generally < 0.1 for both step and stride length and bias-corrected gait kinematics. We observed a median step and stride length error of ~16 mm and ~12 mm respectively, with median bias-corrected kinematic errors ranging from 1.5 to 3.8 degrees across lower extremity joints. Consistent with the calibrated ECE, the magnitude of the model's predicted uncertainty correlated strongly with observed error measures. These findings indicate that, as designed, the probabilistic model reconstruction quantifies epistemic uncertainty, allowing it to identify unreliable outputs without the need for concurrent ground-truth instrumentation.
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