通过社区级折叠建模,提升脑图谱个体化映射的鲁棒性与解剖一致性。
Community-Level Modeling of Gyral Folding Patterns for Robust and Anatomically Informed Individualized Brain Mapping
- 用拓扑与连接特征联合编码3铰链回沟,构建社区级折叠单元。
- 在1000+人脑连接组数据上,形态方差降低,对齐效果优于现有方法。
- 适合神经解剖学、个体化脑图谱研究者,尤其关注跨个体匹配问题。
皮层折叠具有显著的个体差异,但仍保留稳定的解剖标志点,可用于精细表征皮层组织。其中,三铰链回沟(3HG)作为关键折叠基本单元,表现出一致拓扑结构但形态、连接和功能存在有意义差异。现有基于标志点的方法通常独立建模每个3HG,忽略了3HG构成更高阶折叠社区以捕捉中尺度结构的事实。这种简化削弱了解剖表达能力,使一对一匹配对位置变异和噪声敏感。我们提出一种谱图表示学习框架,建模社区级折叠单元而非孤立地标。每个3HG采用结合表面拓扑与结构连接的双特征表示。通过个体特异性谱聚类识别连贯折叠社区,并进行拓扑优化以保持解剖连续性。针对跨被试对应关系,引入联合形态-几何匹配,协同优化几何与形态相似性。在超过1000名人类连接组项目受试者中,所得社区展现出更低的形态方差、更强的模块化组织、更优的半球一致性及更优的对齐性能,优于基于图谱、地标或嵌入的基线方法。结果表明,社区级建模为个体化皮层表征提供了稳健且解剖基础坚实的框架,实现了可靠的跨个体对应。
原文摘要 · Abstract (English)
Cortical folding exhibits substantial inter-individual variability while preserving stable anatomical landmarks that enable fine-scale characterization of cortical organization. Among these, the three-hinge gyrus (3HG) serves as a key folding primitive, showing consistent topology yet meaningful variations in morphology, connectivity, and function. Existing landmark-based methods typically model each 3HG independently, ignoring that 3HGs form higher-order folding communities that capture mesoscale structure. This simplification weakens anatomical representation and makes one-to-one matching sensitive to positional variability and noise. We propose a spectral graph representation learning framework that models community-level folding units rather than isolated landmarks. Each 3HG is encoded using a dual-profile representation combining surface topology and structural connectivity. Subject-specific spectral clustering identifies coherent folding communities, followed by topological refinement to preserve anatomical continuity. For cross-subject correspondence, we introduce Joint Morphological-Geometric Matching, jointly optimizing geometric and morphometric similarity. Across over 1000 Human Connectome Project subjects, the resulting communities show reduced morphometric variance, stronger modular organization, improved hemispheric consistency, and superior alignment compared with atlas-based and landmark-based or embedding-based baselines. These findings demonstrate that community-level modeling provides a robust and anatomically grounded framework for individualized cortical characterization and reliable cross-subject correspondence.
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