arXiv:2602.02795eess.IV2026-02

用扩散模型提升角膜OCT图像分辨率4倍并去噪,更清晰看懂眼组织结构。

Super-Resolution and Denoising of Corneal B-Scan OCT Imaging Using Diffusion Model Plug-and-Play Priors

  • 将图像重建建模为贝叶斯逆问题,结合马尔可夫链蒙特卡洛与预训练生成先验
  • 在真实活体数据上实现4倍分辨率提升,显著改善层间边界清晰度和噪声抑制
  • 方法可推广至其他医学影像超分辨与去噪任务,适合临床科研人员参考

光学相干断层扫描(OCT)在角膜成像中对术前规划和诊断至关重要。然而高速采集常导致空间分辨率下降和斑点噪声增加,影响准确解读。本文提出一种基于扩散模型插件式先验(PnP)的先进超分辨率框架,实现4倍空间分辨率提升并有效去噪。该方法将重建建模为严谨的贝叶斯逆问题,结合马尔可夫链蒙特卡洛采样与预训练生成先验,确保解剖结构一致性。我们使用活体鱼眼角膜数据集进行全面验证,评估其在多种临床场景下的鲁棒性与可扩展性。与双三次插值、传统监督型U-Net基线及其它扩散先验相比,本方法始终能生成更精确的解剖结构,提升角膜各层辨识度,且噪声抑制效果更优。定量结果显示,在峰值信噪比、结构相似性指数及感知质量指标上均达当前最优水平。本研究证明扩散驱动的插件式重建在实现高保真、高分辨率OCT成像方面的潜力,支持更可靠的临床评估,并推动图像引导干预技术发展。结果表明该方法可拓展至其他需稳健超分辨与去噪的生物医学成像领域。

原文摘要 · Abstract (English)

Optical coherence tomography (OCT) is pivotal in corneal imaging for both surgical planning and diagnosis. However, high-speed acquisitions often degrade spatial resolution and increase speckle noise, posing challenges for accurate interpretation. We propose an advanced super-resolution framework leveraging diffusion model plug-and-play (PnP) priors to achieve 4x spatial resolution enhancement alongside effective denoising of OCT Bscan images. Our approach formulates reconstruction as a principled Bayesian inverse problem, combining Markov chain Monte Carlo sampling with pretrained generative priors to enforce anatomical consistency. We comprehensively validate the framework using \emph{in vivo} fisheye corneal datasets, to assess robustness and scalability under diverse clinical settings. Comparative experiments against bicubic interpolation, conventional supervised U-Net baselines, and alternative diffusion priors demonstrate that our method consistently yields more precise anatomical structures, improved delineation of corneal layers, and superior noise suppression. Quantitative results show state-of-the-art performance in peak signal-to-noise ratio, structural similarity index, and perceptual metrics. This work highlights the potential of diffusion-driven plug-and-play reconstruction to deliver high-fidelity, high-resolution OCT imaging, supporting more reliable clinical assessments and enabling advanced image-guided interventions. Our findings suggest the approach can be extended to other biomedical imaging modalities requiring robust super-resolution and denoising.

医学影像超分辨率扩散模型OCT

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