针对幼儿脑白质束提出新分割方法,精度显著优于现有技术。
Personalized White Matter Bundle Segmentation for Early Childhood
- 基于TractSeg架构改进输入与损失函数,适配儿科白质束定义。
- 在56例手动标注数据上,16个区域的骰指数均显著提升。
- 结合两模型输出生成更稳定连续的个体化白质图谱,适合临床研究。
从扩散磁共振成像中进行白质分割的方法包括基于轨迹聚类和束掩膜划定等,但尚无专为儿童设计的方法。我们假设采用类似TractSeg的深度学习模型,能提升算法生成掩膜与专家标注之间的相似性。基于56例手动标注的白质束数据集,受TractSeg的2D UNet架构启发,我们调整输入以匹配儿科专家定义的束结构,采用k折交叉验证评估,损失函数改用带掩膜的Dice损失。对比专家标注数据集,评估了16个主要感兴趣区域的骰指数、体积重叠和体积过量。通过威尔科克斯符号秩检验并进行错误发现率校正,发现除一个束的体积重叠外,其余所有束在所有指标上均具统计学显著性差异。将TractSeg与本模型输出合并生成60标签图谱,结果显示在TractSeg无法生成解剖合理输出的病例中,组合结果呈现更平滑连续的掩膜。该方法提升了白质通路分割精度,有助于在群体水平理解神经发育,并为儿科白质疾病提供可靠的个体解剖估计。
原文摘要 · Abstract (English)
White matter segmentation methods from diffusion magnetic resonance imaging range from streamline clustering-based approaches to bundle mask delineation, but none have proposed a pediatric-specific approach. We hypothesize that a deep learning model with a similar approach to TractSeg will improve similarity between an algorithm-generated mask and an expert-labeled ground truth. Given a cohort of 56 manually labelled white matter bundles, we take inspiration from TractSeg's 2D UNet architecture, and we modify inputs to match bundle definitions as determined by pediatric experts, evaluation to use k fold cross validation, the loss function to masked Dice loss. We evaluate Dice score, volume overlap, and volume overreach of 16 major regions of interest compared to the expert labeled dataset. To test whether our approach offers statistically significant improvements over TractSeg, we compare Dice voxels, volume overlap, and adjacency voxels with a Wilcoxon signed rank test followed by false discovery rate correction. We find statistical significance across all bundles for all metrics with one exception in volume overlap. After we run TractSeg and our model, we combine their output masks into a 60 label atlas to evaluate if TractSeg and our model combined can generate a robust, individualized atlas, and observe smoothed, continuous masks in cases that TractSeg did not produce an anatomically plausible output. With the improvement of white matter pathway segmentation masks, we can further understand neurodevelopment on a population level scale, and we can produce reliable estimates of individualized anatomy in pediatric white matter diseases and disorders.
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