通过激活引导的结构化正则化，提升大模型量化抗异常值能力。

Weight-only post-training quantization (PTQ) is crucial for efficient Large Language Model (LLM) deployment but suffers from accuracy degradation caused by weight and activation outliers. Existing mitigation strategies often face critical limitations: they either yield insufficient outlier suppression or incur significant deployment inefficiencies, such as inference latency, heavy preprocessing, or reliance on complex operator fusion. To resolve these limitations, we leverage a key insight: over-parameterized LLMs often converge to Flat Minima, implying a vast equivalent solution space where weights can be adjusted without compromising accuracy. Building on this, we propose Astro, an Activation-guided Structured Regularization framework designed to suppress the negative effects of outliers in a hardware-friendly and efficient manner. Leveraging the activation-guided regularization objective, Astro actively reconstructs intrinsically robust weights, aggressively suppressing weight outliers corresponding to high-magnitude activations without sacrificing model accuracy. Crucially, Astro introduces zero inference latency and is orthogonal to mainstream quantization methods like GPTQ. Extensive experiments show that Astro achieves highly competitive performance; notably, on LLaMA-2-7B, it achieves better performance than complex learning-based rotation methods with almost 1/3 of the quantization time.